SMAD2 Protein Cell Signaling Reagents Transcription Proteins


HomeCell Signaling Reagents - Transcription ProteinsSMAD2 Protein

SMAD2 Protein (S11-30G)

Catalog Number Pack Size Price (USD)  
SMAD2 Protein S11-30G-20 20 ug $195   SMAD2 Protein Add to Cart
SMAD2 Protein S11-30G-50 50 ug $395   SMAD2 Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human SMAD2 was expressed in E. coli cells using an N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Human
Sequence: Full Length
Genbank Number: NM_001003652
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~90 kDa

Gene Aliases: JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, MGC22139, MGC34440

Scientific Background: SMADs are essential intracellular components for the signal transduction of TGFβ family members. SMAD2 is an intracellular mediator of TGFβ family and activin type 1 receptor (1). SMAD2 mediate TGFβ signaling to regulate cell growth and differentiation. SMAD2 is released from cytoplasmic retention by TGFβ receptor-mediated phosphorylation. The phosphorylated SMAD2 then forms a heterodimeric complex with SMAD4, and this complex translocates from cytoplasm into nucleus. By interacting with DNA-binding proteins, SMAD2 complexes then positively or negatively regulate the transcription of target genes. Inactivating mutations in SMAD2 have been found in various cancers (2).

References
1. Masayuki, F. et al: Identification and Characterization of Constitutively Active Smad2 Mutants: Evaluation of Formation of Smad Complex and Subcellular Distribution. Molecular Endocrinol. 2000; 14 (10): 1583-1591.

2. Eppert, K. et al: MADR2 maps to 18q21 and encodes a TGF-beta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell. 1996; 86: 543-552.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




SMAD2 Protein Research Areas

The SMAD2 Protein product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, WNT Signaling



SMAD2 Protein Related Products Found: Total 13 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes JNK1, Active M33-10G Kinase Assay, Western Blot View JNK1, Active
Signaling Proteins JNK1, Unactive M33-14G Kinase Assay, Western Blot View JNK1, Unactive
Signaling Proteins JNK2, Unactive M34-14G Kinase Assay, Western Blot View JNK2, Unactive
Signaling Proteins JNK3, Unactive M35-14G Kinase Assay, Western Blot View JNK3, Unactive
Signaling Proteins p38 beta, Unactive M36-14G Kinase Assay, Western Blot View p38 beta, Unactive
Signaling Proteins p38 gamma, Unactive M37-14G Kinase Assay, Western Blot View p38 gamma, Unactive
Signaling Proteins p38 delta, Unactive M38-14G Kinase Assay, Western Blot View p38 delta, Unactive
Signaling Proteins p38 alpha, Unactive M39-14G Kinase Assay, Western Blot View p38 alpha, Unactive
Signaling Proteins SMAD4 Protein S13-30G Kinase Assay, Western Blot View SMAD4 Protein
Signaling Proteins SMAD5 Protein S14-30G Kinase Assay, Western Blot View SMAD5 Protein
Signaling Proteins SMAD1 Protein S10-30G Kinase Assay, Western Blot View SMAD1 Protein
Antibodies Anti-SMAD2 S11-63R WB View Anti-SMAD2
Signaling Proteins SMAD9 Protein S17-30G Western Blot View SMAD9 Protein


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferases Active Methyltransferases
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Biochemical Compounds
Biochemical Compounds Kinase Activators Kinase Activators
Biochemical Compounds Kinase Inhibitors Kinase Inhibitors
siRNAs
siRNAs siRNA Controls siRNA Controls
siRNAs siRNA Sets siRNA Sets
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Dioxygenase Proteins Dioxygenase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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