TGFBR1 (ALK5) Active Enzymes Active Kinases


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TGFBR1 (ALK5), Active (T07-11G)

Catalog Number Pack Size Price (USD)  
TGFBR1 (ALK5), Active T07-11G-05 5 ug $205   TGFBR1 (ALK5), Active Add to Cart
TGFBR1 (ALK5), Active T07-11G-10 10 ug $295   TGFBR1 (ALK5), Active Add to Cart
TGFBR1 (ALK5), Active T07-11G-BULK BULK CONTACT US  
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Bulk Pricing for TGFBR1 (ALK5), Active

Product Data Sheet(s)




Description: Recombinant human TGFBR1 (ALK5) (80-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 80-end
Genbank Number: BC071181
   

Storage, Stability and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~66 kDa

Gene Aliases: AAT5, ALK5, SKR4, ALK-5, LDS1A, LSD2A, TGFR-1, ACVRLK4

Scientific Background: TGFβR1 or transforming growth factor, beta-receptor 1 is a member of the TGFβ receptor subfamily and is a ser/thr protein kinase that forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. Mutations in TGFβR1gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors (1). TGFβR1-dependent signaling is required for angiogenesis but not for the development of hematopoietic progenitor cells and functional hematopoiesis (2).

References
1. Singh, K. et.al: TGFBR1 and TGFBR2 mutations in patients with features of Marfan syndrome and Loeys- Dietz syndrome. Hum. Mutat. 27: 770-777, 2006.

2. Larsson, J. et.al: Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J. 20: 1663-1673, 2001.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




TGFBR1 (ALK5), Active Research Areas

The TGFBR1 (ALK5), Active product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, Ser/Thr Kinases, WNT Signaling



TGFBR1 (ALK5), Active Related Products Found: Total 9 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins TGFBR1, Unactive T07-35G Kinase Assay, Western Blot View TGFBR1, Unactive
Signaling Reagents TGFBR1 Peptide T36-58 Peptide Substrate View TGFBR1 Peptide
Enzymes TGFBR2, Active T08-11G Kinase Assay, Western Blot View TGFBR2, Active
Enzymes ALK1, Active A09-11G Kinase Assay, Western Blot View ALK1, Active
Enzymes ALK2, Active A06-11G Kinase Assay, Western Blot View ALK2, Active
Enzymes ALK4, Active A07-11G Kinase Assay, Western Blot View ALK4, Active
Extracellular Ligands TGFB3 T833-40CN Cell Assay View TGFB3
Signaling Proteins ALK7 Protein A08-35G Western Blot View ALK7 Protein
Extracellular Ligands TGFB1 T831-40N Cell Assay View TGFB1


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
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Enzymes Active Phosphatases Active Phosphatases
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Signaling Proteins
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Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
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Signaling Proteins Dioxygenase Proteins Dioxygenase Proteins
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Discovery Services
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Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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