TRAF2 Protein Cell Signaling Reagents Adaptor Proteins


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TRAF2 Protein (T57-30H)
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TRAF2 Protein T57-30H-20 20 ug $195 TRAF2 Protein  40% OFF   TRAF2 Protein Add to Cart
TRAF2 Protein T57-30H-50 50 ug $395 TRAF2 Protein  40% OFF   TRAF2 Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human TRAF2 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Tag: His tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_021138
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~59kDa

Gene Aliases : TRAP, TRAP3, MGC: 45012

Scientific Background: TRAF2 (also known as TNF receptor-associated factor 2) belongs to the TNF receptor associated factor (TRAF) protein family that mediates signal transduction from members of the TNF receptor superfamily (1). TRAF2 is involved in TNF-alpha-mediated activation of MAPK8/JNK and NF-κB pathway. TRAF2 interacts with TNF receptors and forms a heterodimeric complex with TRAF1. The TRAF1-TRAF2 complex interacts with IAPs to mediate the anti-apoptotic signals from TNF receptors. TRAF2 also interacts with TRADD, a TNF receptor associated apoptotic signal transducer, to ensure the recruitment of IAPs for the direct inhibition of caspase activation (2).

References: 
1. Wajant, H. Et al: The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.". Cell. Signal. 2001;13 (6): 389–400.

2. Bradley, J.R., Pober, J.S. Tumor necrosis factor receptor-associated factors (TRAFs).". Oncogene,2001; 20 (44): 6482–91



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




TRAF2 Protein Research Areas

The TRAF2 Protein product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cancer, Inflammation, JNK/SAPK Pathway, NfkB Pathway



TRAF2 Protein Related Products Found: Total 3 Related Products
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Signaling Proteins JNK1, Unactive M33-14G Kinase Assay, Western Blot View JNK1, Unactive


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
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Enzymes Active Phosphatases Active Phosphatases
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Extracellular Ligands
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Signaling Proteins
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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