Storage, Stability, and Shipping
: Store product at –70o
C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Western Blot
: TRAP, TRAP3, MGC: 45012
: TRAF2 (also known as TNF receptor-associated factor 2) belongs to the TNF receptor associated factor (TRAF) protein family that mediates signal transduction from members of the TNF receptor superfamily (1). TRAF2 is involved in TNF-alpha-mediated activation of MAPK8/JNK and NF-κB pathway. TRAF2 interacts with TNF receptors and forms a heterodimeric complex with TRAF1. The TRAF1-TRAF2 complex interacts with IAPs to mediate the anti-apoptotic signals from TNF receptors. TRAF2 also interacts with TRADD, a TNF receptor associated apoptotic signal transducer, to ensure the recruitment of IAPs for the direct inhibition of caspase activation (2).
1. Wajant, H. Et al: The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.". Cell. Signal. 2001;13 (6): 389–400.
2. Bradley, J.R., Pober, J.S. Tumor necrosis factor receptor-associated factors (TRAFs).". Oncogene,2001; 20 (44): 6482–91
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
The TRAF2 Protein product can be utilized in the following research areas, but not limited to:
Apoptosis/Autophagy, Cancer, Inflammation, JNK/SAPK Pathway, NfkB Pathway