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Description: Human active form BMP-2 (283-396) was expressed in E. coli cells and purified by proprietary chromatographic techniques.
: Recombinant protein stored in 1 X PBS, 10% glycerol.
Storage, Stability, and Shipping
: Stored at desiccated below -20o
C. It is stable at 4o
C between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Cell Assay
: Less than 0.1 ng/µg (IEU/µg) of BMP-2.
: ~13.8 kDa
: BMP-2 is a member of the bone morphogenetic protein family that is part of the transforming growth factor-beta (TGFB) superfamily. BMP-2 acts as a disulfide-linked homodimer that induces bone and cartilage formation. BMP2 modulates fibroblast-like synoviocyte cell populations in inflamed synovium (1). BMP2 plays a role in human T-cell differentiation and involve in the long bone formation (2).
1. Lories, R. J. U. et.al: Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis Rheum. 48: 2807-2818, 2003.
2. Cejalvo, T. et.al: Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development. Immunology 121: 94-104, 2007.
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
BMP-2 Research Areas
The BMP-2 product can be utilized in the following research areas, but not limited to:
AKT/PKB Pathway, Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, WNT Signaling