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Description: Human active form IL-2 (21-153) was expressed in E. coli cells and purified by proprietary chromatographic techniques.
: Recombinant protein stored in 1 X PBS, 10% glycerol.
Storage, Stability, and Shipping
: Stored at desiccated below -20o
C. It is stable at 4o
C between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Cell Assay
: Less than 0.1 ng/µg (IEU/µg) of IL-2.
: ~14.5 kDa
: TCGF; lymphokine; IL2
: IL-2 or interleukin 2 is a secreted cytokine which referred to as T-cell growth factor, that is a powerfully immunoregulatory lymphokine that is produced by lectin- or antigen-activated T cells. IL2 can act as a growth hormone that is important for the proliferation of T and B-lymphocytes (1). IL2 expression is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene (2).
1. Lowenthal, J. W. et.al: Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. Nature 315: 669-672, 1985.
2. Hollander, G. A. et.al: Monoallelic expression of the interleukin-2 locus. Science 279: 2118-2121, 1998.
||Activity Assay: Sample Biological Activity Plot. For specific information on a given lot, see related technical data sheet.
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
IL-2 Research Areas
The IL-2 product can be utilized in the following research areas, but not limited to:
AKT/PKB Pathway, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway, PKA/PKC Pathway