Description: Recombinant human TAOK2 (1-314) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Storage, Stability, and Shipping: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~63 kDa

Gene Aliases : PSK, PSK1, TAO1, TAO2, MAP3K17, KIAA0881

Scientific Background: Thousand and one-amino acid protein kinase 2 (TAOK 2) is part of the stress-sensitive kinase cascade and activation of and binding to MKK3 by TAOK2 implicates it in the regulation of the p38-containing stress-responsive MAP kinase pathway (1). TAOK2 protein kinase activates p38 mitogen-activated protein kinase cascade in vitro and in cells by phosphorylating the MAP/ERK kinases MKK3 and MKK6. TAO2 may play an important role in the activation of specific intracellular signaling pathways that are unique to osmotic stress (2).

References: 
1. Hutchison, M. et al: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 1998; 273:28625-32.

2. Chen, Z. et al: TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. J. Biol. Chem. 2003;278:22278-83.

		Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Items in Your Cart (0)