Description: Recombinant human PTPN13 (2169-2485) was expressed in E.coli cells using a N-terminal GST tag.

Storage, Stability, and Shipping: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Phosphatase Assay, Western Blot

Molecular Weight: ~61 kDa

Gene Aliases: PTP-BAS, PNP1, FAP-1, PTP1E, PTPL1, PTPLE, PTP-BL, DKFZp686J1497

Scientific Background: PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN13 is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif (1). PTPN13 binds to a negative regulatory domain in Fas that inhibits Fas-induced apoptosis (2).

References: 
1. Saras, J. et al: Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. J. Biol. Chem. 269: 24082-24089, 1994.

2. Inazawa, J. et al: PTPN13, a Fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3. Genomics 31: 240-242, 1996.

		Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Items in Your Cart (0)