PTPN2 (TC-PTP) Active Enzymes Active Phosphatases


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PTPN2 (TC-PTP), Active (P29-20G)
Catalog Number Pack Size Price (USD)  
PTPN2 (TC-PTP), Active P29-20G-05 5 ug $145   PTPN2 (TC-PTP), Active Add to Cart
PTPN2 (TC-PTP), Active P29-20G-10 10 ug $205   PTPN2 (TC-PTP), Active Add to Cart
PTPN2 (TC-PTP), Active P29-20G-BULK BULK CONTACT US  
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Bulk Pricing for PTPN2 (TC-PTP), Active

Product Data Sheet(s)




Description: Recombinant full length human PTPN2 was expressed in E. coli cells using a N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Human
Sequence: Full length
Genbank Number: NM_080422
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Phosphatase Assay, Western Blot

Molecular Weight: ~69 kDa

Gene Aliases: TC-PTP, PTPT, TCELLPTP, TCPTP

Scientific Background: Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family (1). By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction (2).

References: 
1. Gupta, S. et al: A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis. FEBS Lett. 2002; 532(1-2):61-6.

2. Yamamoto, T. et al: The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem. Biophys. Res. Commun.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PTPN2 (TC-PTP), Active Research Areas

The PTPN2 (TC-PTP), Active product can be utilized in the following research areas, but not limited to:

Inflammation, JAK/STAT Pathway, Metabolic Disorder, Neurobiology, Phosphatases



PTPN2 (TC-PTP), Active Related Products Found: Total 4 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes PTPN1 (PTP1B), Active P28-20G Phosphatase Assay, Western Blot View PTPN1 (PTP1B), Active
Signaling Reagents Phosphatase Assay Buffer I P01-09 Phosphatase Assay View Phosphatase Assay Buffer I
Enzymes PTPN12 (PTP-PEST), Active P39-21G Phosphatase Assay, Western Blot View PTPN12 (PTP-PEST), Active
Signaling Proteins PTPRM (PTP- mu) Protein P58-35G Western Blot View PTPRM (PTP- mu) Protein


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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