PTPN6 (SHP1) Active Enzymes Active Phosphatases


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PTPN6 (SHP1), Active (P33-20G)
Catalog Number Pack Size Price (USD)  
PTPN6 (SHP1), Active P33-20G-05 5 ug $205   PTPN6 (SHP1), Active Add to Cart
PTPN6 (SHP1), Active P33-20G-10 10 ug $295   PTPN6 (SHP1), Active Add to Cart
PTPN6 (SHP1), Active P33-20G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant full length human PTPN6 was expressed in E.coli cells using an N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Human
Sequence: Full length
Genbank Number: NM_080548
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Phosphatase Assay, Western Blot

Molecular Weight: ~93 kDa

Gene Aliases: SHP1; SHP-1; HCP; HCPH; HPTP1C; PTP-1C; SHP-1L; SH-PTP1

Scientific Background: PTPN6 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells (1). The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity (2). The PTPN6 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.

References: 
1. Adachi, M. et al: Protein-tyrosine phosphatase expression in pre-B cell NALM-6. Cancer Res. 52: 737-740, 1992.

2. Pettiford, S M. et al: The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP. Oncogene. 2000 Feb 17;19(7):858-69.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PTPN6 (SHP1), Active Research Areas

The PTPN6 (SHP1), Active product can be utilized in the following research areas, but not limited to:

Cancer, Inflammation, JAK/STAT Pathway, Neurobiology, Phosphatases



PTPN6 (SHP1), Active Related Products Found: Total 11 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes PTPN11 (SHP2), Active P38-21G Phosphatase Assay, Western Blot View PTPN11 (SHP2), Active
Signaling Reagents Phosphatase Assay Buffer II P02-09 Phosphatase Assay View Phosphatase Assay Buffer II
Signaling Reagents Tyr-phosphopeptide-2 T70-58 Phosphatase Assay View Tyr-phosphopeptide-2
Enzymes AMPK (A1/B1/G1), Active P47-10H Kinase Assay, Western Blot View AMPK (A1/B1/G1), Active
Enzymes AMPK (A2/B1/G1), Active P48-10H Kinase Assay, Western Blot View AMPK (A2/B1/G1), Active
Enzymes AMPK (A1/B1/G2), Active P55-10H Kinase Assay, Western Blot View AMPK (A1/B1/G2), Active
Enzymes AMPK (A1/B1/G3), Active P56-10H Kinase Assay, Western Blot View AMPK (A1/B1/G3), Active
Enzymes AMPK (A1/B2/G1), Active P50-10H Kinase Assay, Western Blot View AMPK (A1/B2/G1), Active
Enzymes JAK2, Active J02-11H Kinase Assay, Western Blot View JAK2, Active
Antibodies Anti-SHP2 P38-63R WB View Anti-SHP2
Signaling Reagents Thr-phosphopeptide T69-58 Phosphatase Assay View Thr-phosphopeptide


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
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Extracellular Ligands
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Signaling Proteins
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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