PDE8B Active Enzymes Active Phosphodiesterases


Home › Enzymes - Active Phosphodiesterases › PDE8B, Active

PDE8B, Active (P96-31BG)
Catalog Number Pack Size Price (USD)  
PDE8B, Active P96-31BG-05 5 ug $235   PDE8B, Active Add to Cart
PDE8B, Active P96-31BG-10 10 ug $345   PDE8B, Active Add to Cart
PDE8B, Active P96-31BG-BULK BULK CONTACT US  
* Prices listed in the "shopping cart" are not discount inclusive. Promotional Prices will be applied internally during the processing of orders and net totals adjusted accordingly.

Bulk Pricing for PDE8B, Active

Product Data Sheet(s)




Description: Recombinant human PDE8B (113-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 113-end
Genbank Number: NM_003719
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: PDE Assay

Molecular Weight: ~115 kDa

Gene Aliases: ADSD; FLJ11212; PPNAD3

Scientific Background: PDE8B or phosphodiesterase 8B is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP (1). The recombinant PDE8B exhibits cAMP-PDE activity that is resistant to several PDE inhibitors. The cAMP hydrolytic activity of PDE8B is unaffected by cGMP and it does not display any cGMP mediated hydrolysis. Defects in PDE8B are a cause of autosomal dominant striatal degeneration (ADSD) (2). PDE8B plays a prominent role in degrading cAMP expression in human embryonic kidney cells.

References: 
1. Hayashi, M. et.al: Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. Biochem. Biophys. Res. Commun. 297: 1253-1258, 2002.

2. Horvath, A. et.al: A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex. Europ. J. Hum. Genet. 16: 1245-1253, 2008.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PDE8B, Active Research Areas

The PDE8B, Active product can be utilized in the following research areas, but not limited to:

Cardiovascular Disease, Inflammation, Phosphodiesterases



PDE8B, Active Related Products Found: Total 20 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes PDE10A, Active P98-31G PDE Assay View PDE10A, Active
Enzymes PDE1A, Active P89-30H PDE Assay View PDE1A, Active
Enzymes PDE1B, Active P89-30BG PDE Assay View PDE1B, Active
Enzymes PDE1C, Active P89-30CG PDE Assay View PDE1C, Active
Enzymes PDE2A, Active P90-30G PDE Assay View PDE2A, Active
Enzymes PDE3A, Active P91-31G PDE Assay View PDE3A, Active
Enzymes PDE3B, Active P91-31BG PDE Assay View PDE3B, Active
Enzymes PDE4A, Active P92-31G PDE Assay View PDE4A, Active
Enzymes PDE4B, Active P92-31BG PDE Assay View PDE4B, Active
Enzymes PDE4C, Active P92-31CG PDE Assay View PDE4C, Active
Enzymes PDE4D, Active P92-31DG PDE Assay View PDE4D, Active
Enzymes PDE5A, Active P93-31G PDE Assay View PDE5A, Active
Enzymes PDE6A, Active P94-31G PDE Assay View PDE6A, Active
Enzymes PDE6B, Active P94-30BG PDE Assay View PDE6B, Active
Enzymes PDE7A, Active P95-31G PDE Assay View PDE7A, Active
Enzymes PDE7B, Active P95-30BG PDE Assay View PDE7B, Active
Enzymes PDE8A, Active P96-30G PDE Assay View PDE8A, Active
Enzymes PDE9A, Active P97-30G PDE Assay View PDE9A, Active
Signaling Proteins PDE12 Protein P100-30G PDE Assay View PDE12 Protein
Signaling Proteins PDE6C Protein P94-34CG Western Blot View PDE6C Protein


Items in Your Cart (0)
Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




Keep in touch, join us on:
PDE8B, Active Enzymes Active Phosphodiesterases    PDE8B, Active Enzymes Active Phosphodiesterases    PDE8B, Active Enzymes Active Phosphodiesterases