14-3-3 zeta Protein Cell Signaling Reagents Cell Stress & Chaperone Proteins


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14-3-3 zeta Protein (Y92-30N)
Catalog Number Pack Size Price (USD)  
14-3-3 zeta Protein Y92-30N-20 20 ug $145 14-3-3 zeta Protein  40% OFF   14-3-3 zeta Protein Add to Cart
14-3-3 zeta Protein Y92-30N-50 50 ug $305 14-3-3 zeta Protein  40% OFF   14-3-3 zeta Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human tag-free 14-3-3zeta was expressed in E. coli cells.
Tag: tag-free
Expression System: E.coli
Species: Human
Sequence: Full length
Genbank Number: NM_003406
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~29kDa

Gene Aliases : 14-3-3 zeta, YWHAZ, KCIP-1, MGC111427, MGC126532, MGC138156

Scientific Background: 14-3-3ζ (also known as tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3ζ protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis (1). 14-3-3ζ protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (2).

References: 
1. Li, Z. et al: Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation.Proc NatlAcadSci U S A. 2008; 105(1):162-7.

2. Niemantsverdriet, M. et al: Cellular functions of 14-3-3 zeta in apoptosis and cell adhesion emphasize its oncogenic character.Oncogene. 2008;27(9):1315-9. 2007



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




14-3-3 zeta Protein Research Areas

The 14-3-3 zeta Protein product can be utilized in the following research areas, but not limited to:

AKT/PKB Pathway, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, WNT Signaling



14-3-3 zeta Protein Related Products Found: Total 15 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins 14-3-3 sigma Protein Y86-30N Western Blot View 14-3-3 sigma Protein
Signaling Proteins 14-3-3 alpha/beta Protein Y71-30N Western Blot View 14-3-3 alpha/beta Protein
Signaling Proteins 14-3-3 epsilon Protein Y75-30N Western Blot View 14-3-3 epsilon Protein
Signaling Proteins 14-3-3 theta Protein Y84-30N Western Blot View 14-3-3 theta Protein
Signaling Proteins 14-3-3 alpha/beta Protein Y71-30G Western Blot View 14-3-3 alpha/beta Protein
Signaling Proteins 14-3-3 epsilon Protein Y75-30G Western Blot View 14-3-3 epsilon Protein
Signaling Proteins 14-3-3 theta Protein Y84-30G Western Blot View 14-3-3 theta Protein
Signaling Proteins 14-3-3 sigma Protein Y86-30G Western Blot View 14-3-3 sigma Protein
Signaling Proteins 14-3-3 zeta Protein Y92-30G Western Blot View 14-3-3 zeta Protein
Enzymes AKT1, Active A16-10G Kinase Assay, Western Blot View AKT1, Active
Enzymes MARK1, Active M43-10G Kinase Assay, Western Blot View MARK1, Active
Enzymes MARK3, Active M45-10G Kinase Assay, Western Blot View MARK3, Active
Signaling Reagents IRS1 (N-Term) Protein I40-35G Kinase Assay, Western Blot View IRS1 (N-Term) Protein
Signaling Proteins BAX Protein B14-30G Western Blot View BAX Protein
Signaling Reagents IRS1 (C-Term) Protein I40-31G Kinase Assay, Western Blot View IRS1 (C-Term) Protein


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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