Description: Recombinant human IL-18 was expressed in E. coli cells and purified by proprietary chromatographic techniques.

Formulation: Recombinant protein stored in 1 X PBS, 10% glycerol.

Storage, Stability, and Shipping: Stored at desiccated below -20^oC. It is stable at 4^oC between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Cell Assay

Endotoxin Level: Less than 0.1 ng/µg (IEU/µg) of IL-18

Molecular Weight: ~18 kDa

Gene Aliases: IGIF, IL-18, IL-1g, IL1F4, MGC12320

Scientific Background: IL18 or interleukin 18 (interferon-gamma-inducing factor) is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells (1). IL18 helps in regulates the acute GVHD by enhancing FAS-mediated apoptosis of donor T cells early after BMT in an IFNG-dependent manner. IL18 plays a major role in the pathogenesis of the autoimmune syndrome of lpr mice and that a reduction in IL18 activity could be a therapeutic strategy in autoimmune diseases (2). IL18 also play an important role in homeostasis of energy intake and insulin sensitivity.

References: 
1. Okamura, H. et.al: Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378: 88-91, 1995.

2. Bossu, P. et.al: IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease. Proc. Nat. Acad. Sci. 100: 14181-14186, 2003.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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