EPHA1 Active Enzymes Active Kinases


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EPHA1, Active (E13-11G)
Catalog Number Pack Size Price (USD)  
EPHA1, Active E13-11G-05 5 ug $205   EPHA1, Active Add to Cart
EPHA1, Active E13-11G-10 10 ug $295   EPHA1, Active Add to Cart
EPHA1, Active E13-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant mouse EPHA1 (569-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Mouse
Sequence: 569-end
Genbank Number: NM_023580
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~71 kDa

Gene Aliases : EPH; EPHT; EPHT1

Scientific Background: EPHA1 is a member of the Eph family of receptor tyrosine kinases that have been implicated in mediating developmental events, particularly in the nervous system (1). Receptors in the Eph subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPHA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. EPHA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer (2).

References: 
1. Kullander, K. et al: Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol. 2002 Jul;3(7):475-86.

2. Hafner, C. et al: Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer. Mod Pathol. 2006 Oct;19(10):1369-77



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




EPHA1, Active Research Areas

The EPHA1, Active product can be utilized in the following research areas, but not limited to:

Angiogenesis, Cancer, Cardiovascular Disease, Neurobiology, Receptor Tyrosine Kinases



EPHA1, Active Related Products Found: Total 16 Related Products
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Signaling Reagents Kinase Assay Buffer II K02-09 Kinase Assay View Kinase Assay Buffer II
Enzymes EPHB4, Active E24-11G Kinase Assay, Western Blot View EPHB4, Active
Enzymes EPHB1, Active E21-11G Kinase Assay, Western Blot View EPHB1, Active
Enzymes EPHB3, Active E23-11G Kinase Assay, Western Blot View EPHB3, Active
Signaling Reagents Kinase Dilution Buffer VIII K28-09 Kinase Assay View Kinase Dilution Buffer VIII
Signaling Reagents ATP Stock Solution A50-09 Kinase Assay View ATP Stock Solution
Enzymes EPHA2, Active E14-11G Kinase Assay, Western Blot View EPHA2, Active
Enzymes EPHA3, Active E15-11G Kinase Assay, Western Blot View EPHA3, Active
Enzymes EPHA4, Active E16-11G Kinase Assay, Western Blot View EPHA4, Active
Signaling Reagents Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide
Enzymes EPHB4, Active E24-11H Kinase Assay, Western Blot View EPHB4, Active
Enzymes EPHA6, Active E18-11G Kinase Assay, Western Blot View EPHA6, Active
Enzymes EPHA1, Active E13-18G Kinase Assay, Western Blot View EPHA1, Active
Enzymes EPHA7, Active E19-11G Kinase Assay, Western Blot View EPHA7, Active
Signaling Proteins EPHA8 Protein E20-35G Western Blot View EPHA8 Protein


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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