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MET, Active (M52-11G)
Catalog Number Pack Size Price (USD)  
MET, Active M52-11G-05 5 ug $205   MET, Active Add to Cart
MET, Active M52-11G-10 10 ug $295   MET, Active Add to Cart
MET, Active M52-11G-BULK BULK CONTACT US  
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Bulk Pricing for MET, Active

Product Data Sheet(s)




Description: Recombinant rat MET (958-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Rat
Sequence: 958-end
Genbank Number: X96786
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~74 kDa

Gene Aliases: HGFR

Scientific Background: MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kd (alpha) and 145 kd (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue (1). Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovarian cancers and has been shown to be involved in tumor cell migration and invasion (2).

References: 
1. Giordano, S. et al: Biosynthesis of the protein encoded by the c-met proto-oncogene. Oncogene. 1989 Nov;4(11):1383-8.

2. Iyer, A. et al: Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene. Cell Growth Differ. 1990 Feb;1(2):87-95.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




MET, Active Research Areas

The MET, Active product can be utilized in the following research areas, but not limited to:

Cancer, Receptor Tyrosine Kinases



MET, Active Related Products Found: Total 13 Related Products
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Enzymes AXL, Active A34-11H Kinase Assay, Western Blot View AXL, Active
Enzymes TYRO3, Active T22-11G Kinase Assay, Western Blot View TYRO3, Active
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Signaling Reagents Kinase Dilution Buffer IV K24-09 Kinase Assay View Kinase Dilution Buffer IV
Signaling Reagents ATP Stock Solution A50-09 Kinase Assay View ATP Stock Solution
Enzymes MET, Active M52-18G Kinase Assay, Western Blot View MET, Active
Signaling Reagents Poly (4:1 Glu, Tyr) Peptide P61-58 Kinase Assay View Poly (4:1 Glu, Tyr) Peptide
Enzymes MET (M1250T), Active M52-12BG Kinase Assay, Western Blot View MET (M1250T), Active


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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