Description: Recombinant human RON (983-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Storage, Stability, and Shipping: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~71 kDa

Gene Aliases: MST1R, PTK8, CDw136

Scientific Background: RON is a macrophage stimulating 1 receptor c-met-related tyrosine kinase (1). RON receptor tyrosine kinase interacts with HYAL2 receptor protein, rendering it functionally inactive. HYAL2 is a candidate tumor-suppressor glycosylphosphatidylinositol-anchored cell-surface protein that serves as an entry receptor for jaagsiekte sheep retrovirus, a virus that causes contagious lung cancer in sheep that is morphologically similar to human bronchioloalveolar carcinoma. It was shown that RON liberated from the association with HYAL2 becomes functionally active and activates the Akt and mitogen-activated protein kinase pathways (2).

References: 
1. Wang, M.H. et al: Identification of the ron gene product as the receptor for the human macrophage stimulating protein. Science, 1994; 266 (5182): 117-9.

2. Li, B,Q, et al: "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor. Biochem. Biophys. Res. Commun.1995; 216 (1): 110-8.

		Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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