Receptor Tyrosine Kinases


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Receptor Tyrosine Kinases

Protein Tyrosine Kinases (PTKs) are a class of enzymes that transfer gamma phosphate group from ATP onto hydroxyl moiety of tyrosine containing proteins through a reversible process referred to as phosphorylation. PTKs are divided into two groups: Receptor PTKs (RPTKs), and non-receptor PTKs (NRPTKs).


Cell cycle arrest in response to DNA damage is an important part of the mechanism used in the cell cycle to maintain genomic integrity and the cell cycle checkpoints act as control mechanisms to restrain cell cycle transition after DNA damage. The G1/S cell cycle checkpoint controls the passage of cells into the DNA synthesis phase. Two cyclin-dependent protein kinases, CDK4/6-cyclin D and CDK2-cyclin E, together with the transcription complexes that includes Rb-HDAC and E2F-DP1 are critical for controlling this checkpoint (2).


The G2/M cell cycle checkpoint prevents the cell from entering mitosis during DNA damage and CDK1-cyclin B plays a critical role in this phase of the cell cycle (3). In the presence of DNA damage, activation of DNA-PK, ATM and ATR occurs which allows these protein kinases to phosphorylate p53 (4). This leads to the dissociation of p53 from MDM2, thereby activating its transcriptional activity to synthesize CDK1 inhibitory proteins. In addition, DNA damage leads to the activation of Chk1 and Chk2 which can phosphorylate and inhibit the activity of CDC25, thereby preventing the activation of CDK1. The signaling pathways feeding into the cell cycle incorporate various oncogenes and tumor suppressors and are therefore a central target for genetic alterations in human cancers (5).Defects in many of the proteins that regulate the cell cycle have been implicated in cancer formation and progression. Key among these are p53, the retinoblastoma protein (Rb) and its related proteins, p107 and Rb2/p130, and CDK inhibitors (p15, p16, p18, p19, p21, p27). The Rb (Rb/p16(INK4a)/cyclin D1) and p53 (p14(ARF)/MDM2/p53) pathways are the two main cell-cycle control pathways frequently targeted in tumorigenesis, and the alterations occurring in each pathway depend on the tumor type (6).


Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases ACK, Active A05-11G Kinase Assay, Western Blot View ACK, Active
Primary Antibodies Anti-EGFR E10-63BR WB View Anti-EGFR
Primary Antibodies Anti-EGFR E10-63R WB View Anti-EGFR
Primary Antibodies Anti-FLT3 New Research Category F12-63R WB, ELISA, IF View Anti-FLT3
Primary Antibodies Anti-HER2 New Research Category E27-63R WB, ELISA, IF, IHC View Anti-HER2
Primary Antibodies Anti-PDFGB New Research Category P842-63R WB, ELISA View Anti-PDFGB
Active Kinases AXL (R499C), Active A34-12BG Kinase Assay, Western Blot View AXL (R499C), Active
Active Kinases AXL, Active A34-11H Kinase Assay, Western Blot View AXL, Active
Active Kinases c-MER, Active M51-11G Kinase Assay, Western Blot View c-MER, Active
Cellular Proteins CRKL Protein C53-30H Western Blot View CRKL Protein
Active Kinases DDR1, Active D05-11G Kinase Assay, Western Blot View DDR1, Active
Active Kinases DDR2, Active D06-11BG Kinase Assay, Western Blot View DDR2, Active
Active Kinases EGFR (L858R), Active E10-12BG Kinase Assay, Western Blot View EGFR (L858R), Active
Active Kinases EGFR (L861Q), Active E10-12CG Kinase Assay, Western Blot View EGFR (L861Q), Active
Active Kinases EGFR (T790M L858R), Active E10-12DG Kinase Assay, Western Blot View EGFR (T790M L858R), Active
Active Kinases EGFR (T790M), Active E10-12EG Kinase Assay, Western Blot View EGFR (T790M), Active
Active Kinases EGFR, Active E10-11G Kinase Assay, Western Blot View EGFR, Active
Active Kinases EPHA1, Active E13-11G Kinase Assay, Western Blot View EPHA1, Active
Active Kinases EPHA1, Active E13-18G Kinase Assay, Western Blot View EPHA1, Active
Active Kinases EPHA2, Active E14-11G Kinase Assay, Western Blot View EPHA2, Active
Active Kinases EPHA3, Active E15-11G Kinase Assay, Western Blot View EPHA3, Active
Active Kinases EPHA4, Active E16-11G Kinase Assay, Western Blot View EPHA4, Active
Active Kinases EPHA6, Active E18-11G Kinase Assay, Western Blot View EPHA6, Active
Active Kinases EPHA7, Active E19-11G Kinase Assay, Western Blot View EPHA7, Active
Cellular Proteins EPHA8 Protein E20-35G Western Blot View EPHA8 Protein
Active Kinases EPHB1, Active E21-11G Kinase Assay, Western Blot View EPHB1, Active
Active Kinases EPHB2, Active E22-11G Kinase Assay, Western Blot View EPHB2, Active
Active Kinases EPHB3, Active E23-11G Kinase Assay, Western Blot View EPHB3, Active
Active Kinases EPHB4, Active E24-11G Kinase Assay, Western Blot View EPHB4, Active
Active Kinases EPHB4, Active E24-11H Kinase Assay, Western Blot View EPHB4, Active
Active Kinases FGFR1 (FLT2), Active F04-11G Kinase Assay, Western Blot View FGFR1 (FLT2), Active
Active Kinases FGFR1 (V561M), Active F04-13G Kinase Assay, Western Blot View FGFR1 (V561M), Active
Active Kinases FGFR2, Active F05-11G Kinase Assay, Western Blot View FGFR2, Active
Active Kinases FGFR3 (K650E), Active F06-12CG Kinase Assay, Western Blot View FGFR3 (K650E), Active
Active Kinases FGFR3, Active F06-11G Kinase Assay, Western Blot View FGFR3, Active
Active Kinases FGFR4, Active F07-11G Kinase Assay, Western Blot View FGFR4, Active
Active Kinases FLT1, Active F11-11G Kinase Assay, Western Blot View FLT1, Active
Active Kinases FLT3 (D835Y), Active F12-12BG Kinase Assay, Western Blot View FLT3 (D835Y), Active
Active Kinases FLT3, Active F12-11G Kinase Assay, Western Blot View FLT3, Active
Active Kinases FLT4, Active F13-11G Kinase Assay, Western Blot View FLT4, Active
Active Kinases HER2, Active E27-11G Kinase Assay, Western Blot View HER2, Active
Active Kinases HER4, Active E29-11G Kinase Assay, Western Blot View HER4, Active
Active Kinases IGF1R, Active I02-11H Kinase Assay, Western Blot View IGF1R, Active
Active Kinases InsR, Active I08-11G Kinase Assay, Western Blot View InsR, Active
Active Kinases IRR, Active I07-11G Kinase Assay, Western Blot View IRR, Active
Active Kinases KDR, Active K01-11G Kinase Assay, Western Blot View KDR, Active
Active Kinases MET (M1250T), Active M52-12BG Kinase Assay, Western Blot View MET (M1250T), Active
Active Kinases MET, Active M52-11G Kinase Assay, Western Blot View MET, Active
Active Kinases MET, Active M52-18G Kinase Assay, Western Blot View MET, Active
Active Kinases MST1, Active S25-10G Kinase Assay, Western Blot View MST1, Active
Active Kinases MST3, Active S42-11G Kinase Assay, Western Blot View MST3, Active
Active Kinases MST4, Active M59-10G Kinase Assay, Western Blot View MST4, Active
Active Kinases MUSK, Active M60-11G Kinase Assay, Western Blot View MUSK, Active
Growth Factors PDGF P841-40N Cell Assay View PDGF
Active Kinases PDGFR alpha (D842V), Active P12-12BG Kinase Assay, Western Blot View PDGFR alpha (D842V), Active
Active Kinases PDGFR alpha (T674I), Active P12-12CG Kinase Assay, Western Blot View PDGFR alpha (T674I), Active
Active Kinases PDGFR alpha, Active P12-11G Kinase Assay, Western Blot View PDGFR alpha, Active
Active Kinases PDGFR alpha, Active P12-18G Kinase Assay, Western Blot View PDGFR alpha, Active
Active Kinases PDGFR beta, Active P13-11G Kinase Assay, Western Blot View PDGFR beta, Active
Active Kinases RET (V804L), Active R02-12BG Kinase Assay, Western Blot View RET (V804L), Active
Active Kinases RET (Y791F), Active R02-12CG Kinase Assay, Western Blot View RET (Y791F), Active
Active Kinases RET, Active R02-11G Kinase Assay, Western Blot View RET, Active
Active Kinases RON, Active M58-11G Kinase Assay, Western Blot View RON, Active
Active Kinases ROR1, Active R12-11G Kinase Assay, Western Blot View ROR1, Active
Active Kinases ROR2, Active R13-11G Kinase Assay, Western Blot View ROR2, Active
Active Kinases ROS1, Active R14-11G Kinase Assay, Western Blot View ROS1, Active
Cellular Proteins RYK Protein R28-31G Western Blot View RYK Protein
Active Kinases TEC, Active T03-10G Kinase Assay, Western Blot View TEC, Active
Active Kinases TIE 2, Active T04-11G Kinase Assay, Western Blot View TIE 2, Active
Active Kinases TLK1, Active T10-10G Kinase Assay, Western Blot View TLK1, Active
Active Kinases TRKA, Active N16-11G Kinase Assay, Western Blot View TRKA, Active
Active Kinases TRKB, Active N17-11G Kinase Assay, Western Blot View TRKB, Active
Active Kinases TRKC, Active N18-11H Kinase Assay, Western Blot View TRKC, Active
Active Kinases TYRO3, Active T22-11G Kinase Assay, Western Blot View TYRO3, Active
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases ACK, Active A05-11G Kinase Assay, Western Blot View ACK, Active
Primary Antibodies Anti-EGFR E10-63BR WB View Anti-EGFR
Primary Antibodies Anti-EGFR E10-63R WB View Anti-EGFR
Primary Antibodies Anti-FLT3 New Research Category F12-63R WB, ELISA, IF View Anti-FLT3
Primary Antibodies Anti-HER2 New Research Category E27-63R WB, ELISA, IF, IHC View Anti-HER2
Primary Antibodies Anti-PDFGB New Research Category P842-63R WB, ELISA View Anti-PDFGB
Active Kinases AXL (R499C), Active A34-12BG Kinase Assay, Western Blot View AXL (R499C), Active
Active Kinases AXL, Active A34-11H Kinase Assay, Western Blot View AXL, Active
Active Kinases c-MER, Active M51-11G Kinase Assay, Western Blot View c-MER, Active
Cellular Proteins CRKL Protein C53-30H Western Blot View CRKL Protein
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases DDR1, Active D05-11G Kinase Assay, Western Blot View DDR1, Active
Active Kinases DDR2, Active D06-11BG Kinase Assay, Western Blot View DDR2, Active
Active Kinases EGFR (L858R), Active E10-12BG Kinase Assay, Western Blot View EGFR (L858R), Active
Active Kinases EGFR (L861Q), Active E10-12CG Kinase Assay, Western Blot View EGFR (L861Q), Active
Active Kinases EGFR (T790M L858R), Active E10-12DG Kinase Assay, Western Blot View EGFR (T790M L858R), Active
Active Kinases EGFR (T790M), Active E10-12EG Kinase Assay, Western Blot View EGFR (T790M), Active
Active Kinases EGFR, Active E10-11G Kinase Assay, Western Blot View EGFR, Active
Active Kinases EPHA1, Active E13-11G Kinase Assay, Western Blot View EPHA1, Active
Active Kinases EPHA1, Active E13-18G Kinase Assay, Western Blot View EPHA1, Active
Active Kinases EPHA2, Active E14-11G Kinase Assay, Western Blot View EPHA2, Active
Active Kinases EPHA3, Active E15-11G Kinase Assay, Western Blot View EPHA3, Active
Active Kinases EPHA4, Active E16-11G Kinase Assay, Western Blot View EPHA4, Active
Active Kinases EPHA6, Active E18-11G Kinase Assay, Western Blot View EPHA6, Active
Active Kinases EPHA7, Active E19-11G Kinase Assay, Western Blot View EPHA7, Active
Cellular Proteins EPHA8 Protein E20-35G Western Blot View EPHA8 Protein
Active Kinases EPHB1, Active E21-11G Kinase Assay, Western Blot View EPHB1, Active
Active Kinases EPHB2, Active E22-11G Kinase Assay, Western Blot View EPHB2, Active
Active Kinases EPHB3, Active E23-11G Kinase Assay, Western Blot View EPHB3, Active
Active Kinases EPHB4, Active E24-11G Kinase Assay, Western Blot View EPHB4, Active
Active Kinases EPHB4, Active E24-11H Kinase Assay, Western Blot View EPHB4, Active
Active Kinases FGFR1 (FLT2), Active F04-11G Kinase Assay, Western Blot View FGFR1 (FLT2), Active
Active Kinases FGFR1 (V561M), Active F04-13G Kinase Assay, Western Blot View FGFR1 (V561M), Active
Active Kinases FGFR2, Active F05-11G Kinase Assay, Western Blot View FGFR2, Active
Active Kinases FGFR3 (K650E), Active F06-12CG Kinase Assay, Western Blot View FGFR3 (K650E), Active
Active Kinases FGFR3, Active F06-11G Kinase Assay, Western Blot View FGFR3, Active
Active Kinases FGFR4, Active F07-11G Kinase Assay, Western Blot View FGFR4, Active
Active Kinases FLT1, Active F11-11G Kinase Assay, Western Blot View FLT1, Active
Active Kinases FLT3 (D835Y), Active F12-12BG Kinase Assay, Western Blot View FLT3 (D835Y), Active
Active Kinases FLT3, Active F12-11G Kinase Assay, Western Blot View FLT3, Active
Active Kinases FLT4, Active F13-11G Kinase Assay, Western Blot View FLT4, Active
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases HER2, Active E27-11G Kinase Assay, Western Blot View HER2, Active
Active Kinases HER4, Active E29-11G Kinase Assay, Western Blot View HER4, Active
Active Kinases IGF1R, Active I02-11H Kinase Assay, Western Blot View IGF1R, Active
Active Kinases InsR, Active I08-11G Kinase Assay, Western Blot View InsR, Active
Active Kinases IRR, Active I07-11G Kinase Assay, Western Blot View IRR, Active
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases KDR, Active K01-11G Kinase Assay, Western Blot View KDR, Active
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases MET (M1250T), Active M52-12BG Kinase Assay, Western Blot View MET (M1250T), Active
Active Kinases MET, Active M52-11G Kinase Assay, Western Blot View MET, Active
Active Kinases MET, Active M52-18G Kinase Assay, Western Blot View MET, Active
Active Kinases MST1, Active S25-10G Kinase Assay, Western Blot View MST1, Active
Active Kinases MST3, Active S42-11G Kinase Assay, Western Blot View MST3, Active
Active Kinases MST4, Active M59-10G Kinase Assay, Western Blot View MST4, Active
Active Kinases MUSK, Active M60-11G Kinase Assay, Western Blot View MUSK, Active
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Growth Factors PDGF P841-40N Cell Assay View PDGF
Active Kinases PDGFR alpha (D842V), Active P12-12BG Kinase Assay, Western Blot View PDGFR alpha (D842V), Active
Active Kinases PDGFR alpha (T674I), Active P12-12CG Kinase Assay, Western Blot View PDGFR alpha (T674I), Active
Active Kinases PDGFR alpha, Active P12-11G Kinase Assay, Western Blot View PDGFR alpha, Active
Active Kinases PDGFR alpha, Active P12-18G Kinase Assay, Western Blot View PDGFR alpha, Active
Active Kinases PDGFR beta, Active P13-11G Kinase Assay, Western Blot View PDGFR beta, Active
Active Kinases RET (V804L), Active R02-12BG Kinase Assay, Western Blot View RET (V804L), Active
Active Kinases RET (Y791F), Active R02-12CG Kinase Assay, Western Blot View RET (Y791F), Active
Active Kinases RET, Active R02-11G Kinase Assay, Western Blot View RET, Active
Active Kinases RON, Active M58-11G Kinase Assay, Western Blot View RON, Active
Active Kinases ROR1, Active R12-11G Kinase Assay, Western Blot View ROR1, Active
Active Kinases ROR2, Active R13-11G Kinase Assay, Western Blot View ROR2, Active
Active Kinases ROS1, Active R14-11G Kinase Assay, Western Blot View ROS1, Active
Cellular Proteins RYK Protein R28-31G Western Blot View RYK Protein
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Active Kinases TEC, Active T03-10G Kinase Assay, Western Blot View TEC, Active
Active Kinases TIE 2, Active T04-11G Kinase Assay, Western Blot View TIE 2, Active
Active Kinases TLK1, Active T10-10G Kinase Assay, Western Blot View TLK1, Active
Active Kinases TRKA, Active N16-11G Kinase Assay, Western Blot View TRKA, Active
Active Kinases TRKB, Active N17-11G Kinase Assay, Western Blot View TRKB, Active
Active Kinases TRKC, Active N18-11H Kinase Assay, Western Blot View TRKC, Active
Active Kinases TYRO3, Active T22-11G Kinase Assay, Western Blot View TYRO3, Active
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
Receptor Tyrosine Kinases Product Listing Found: Total 74 Products Matching Research Category Receptor Tyrosine Kinases
Product Type Product Name Catalog Number Application Pack Sizes
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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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