AURORA C Unactive Cell Signaling Reagents Unactive Kinases


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AURORA C, Unactive (A33-14G)
Catalog Number Pack Size Price (USD)  
AURORA C, Unactive A33-14G-20 20 ug $195 AURORA C, Unactive  40% OFF   AURORA C, Unactive Add to Cart
AURORA C, Unactive A33-14G-50 50 ug $395 AURORA C, Unactive  40% OFF   AURORA C, Unactive Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human AURORA C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_003160
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~61 kDa

Gene Aliases: AURKC, AIE2, AIK3, AurC, STK13, aurora-C

Scientific Background: AURORA C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. AURORA C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors (1). AURORA C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. AURORA C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development (2).

References: 
1. Steven, L. et al: Targeting Aurora-2 Kinase in Cancer. Molecular Cancer Therapeutics. 2003;2: 589-595.

2. Shingo, T. et al: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes to Cells. 2004; 9: 383-397.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




AURORA C, Unactive Research Areas

The AURORA C, Unactive product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle, Ser/Thr Kinases



AURORA C, Unactive Related Products Found: Total 5 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins AURORA A, Unactive A28-14G Kinase Assay, Western Blot View AURORA A, Unactive
Signaling Proteins AURORA B, Unactive A31-14G Kinase Assay, Western Blot View AURORA B, Unactive
Enzymes AURORA A, Active A28-10G Kinase Assay, Western Blot View AURORA A, Active
Enzymes AURORA A, Active A28-18G Kinase Assay, Western Blot View AURORA A, Active
Enzymes AURORA B, Active A31-10G Kinase Assay, Western Blot View AURORA B, Active


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Product Types
Enzymes
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Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
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Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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