Storage, Stability, and Shipping
: Store product at –70o
C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Kinase Assay, Western Blot
: ~61 kDa
: AURKC, AIE2, AIK3, AurC, STK13, aurora-C
: AURORA C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. AURORA C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors (1). AURORA C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. AURORA C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development (2).
1. Steven, L. et al: Targeting Aurora-2 Kinase in Cancer. Molecular Cancer Therapeutics. 2003;2: 589-595.
2. Shingo, T. et al: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes to Cells. 2004; 9: 383-397.
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
The AURORA C, Unactive product can be utilized in the following research areas, but not limited to:
Cancer, Cell Cycle, Ser/Thr Kinases