CK2 alpha 2 Active Enzymes Active Kinases


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CK2 alpha 2, Active (C71-10G)
Catalog Number Pack Size Price (USD)  
CK2 alpha 2, Active C71-10G-05 5 ug $205   CK2 alpha 2, Active Add to Cart
CK2 alpha 2, Active C71-10G-10 10 ug $295   CK2 alpha 2, Active Add to Cart
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Product Data Sheet(s)




Description: Full length recombinant human CK2 alpha 2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: NM_001896
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~64 kDa

Gene Aliases: CSNK2A2; CKII-alpha 2; CK2A2

Scientific Background: CK2α2 or casein kinase II alpha 2 is a member of the CK2 family of Ser/Thr protein kinases. CK2a2 plays a fundamental role in cell function and is involved in DNA replication, regulation of basal and inducible transcription, translation and control of metabolism. CK2α2 prefers utilization of acidic proteins such as caseins as substrates. The CK2a2 holoenzyme is a tetramer composed of an alpha chain, an alpha' and two beta chains. The alpha and alpha' chains contain the catalytic site. CK2α2 is also a component of CK2-SPT16-SSRP1 complex comprised of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B (1). This complex associates following UV irradiation. CK2a2 act as a candidate gene for inherited abnormalities of sperm morphogenesis (2).

References: 
1. Keller, D. M. et.al: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Molec. Cell 7: 283-292, 2001.

2. Xu, X. et.al: Globozoospermia in mice lacking the casein kinase II alpha-prime catalytic subunit. Nature Genet. 23: 118-121, 1999.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




CK2 alpha 2, Active Research Areas

The CK2 alpha 2, Active product can be utilized in the following research areas, but not limited to:

Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling



CK2 alpha 2, Active Related Products Found: Total 8 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes CK1 alpha 1, Active C64-10G Kinase Assay, Western Blot View CK1 alpha 1, Active
Enzymes CK1 gamma 2, Active C68-10BG Kinase Assay, Western Blot View CK1 gamma 2, Active
Enzymes CK1 delta, Active C65-10G Kinase Assay, Western Blot View CK1 delta, Active
Enzymes CK1 epsilon, Active C66-10G Kinase Assay, Western Blot View CK1 epsilon, Active
Enzymes CK2 alpha 1, Active C70-10G Kinase Assay, Western Blot View CK2 alpha 1, Active
Signaling Reagents CK2 Substrate C08-58 Kinase Assay View CK2 Substrate
Enzymes CK1 gamma 3, Active C68-10CG Kinase Assay, Western Blot View CK1 gamma 3, Active
Enzymes CK1 gamma 1, Active C68-11G Kinase Assay, Western Blot View CK1 gamma 1, Active


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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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