EIF2AK4 (GCN2) Active Enzymes Active Kinases


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EIF2AK4 (GCN2), Active (E12-11G)
Catalog Number Pack Size Price (USD)  
EIF2AK4 (GCN2), Active E12-11G-05 5 ug $205   EIF2AK4 (GCN2), Active Add to Cart
EIF2AK4 (GCN2), Active E12-11G-10 10 ug $295   EIF2AK4 (GCN2), Active Add to Cart
EIF2AK4 (GCN2), Active E12-11G-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human EIF2AK4 (192-1024) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: 192-1024
Genbank Number: NM_001013703
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~132 kDa

Gene Aliases: GCN2; KIAA1338

Scientific Background: EIF2AK4 or eukaryotic translation initiation factor 2 alpha kinase 4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses (1). The EIF2AK4 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid (2).

References: 
1. Berlanga, J. J. et.al: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2-alpha kinase. Europ. J. Biochem. 265: 754-762, 1999.

2. Guo, F. et.al: The GCN2 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab. 5: 103-114, 2007.



  Specific Activity:  Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




EIF2AK4 (GCN2), Active Research Areas

The EIF2AK4 (GCN2), Active product can be utilized in the following research areas, but not limited to:

Angiogenesis, Cellular Stress, Inflammation, Neurobiology, Ser/Thr Kinases



EIF2AK4 (GCN2), Active Related Products Found: Total 6 Related Products
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Enzymes EIF2AK3, Active E11-11G Kinase Assay, Western Blot View EIF2AK3, Active
Signaling Reagents RS Repeat Peptide R55-58 Kinase Assay View RS Repeat Peptide
Signaling Reagents EIF2S1 Protein E23-54H Kinase Assay, Western Blot View EIF2S1 Protein
Signaling Reagents Modified EIF2S Peptide E23-58B Kinase Assay View Modified EIF2S Peptide
Signaling Reagents EIF2S Peptide E23-58 Kinase Assay View EIF2S Peptide


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Product Types
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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