Storage, Stability, and Shipping
: Store product at –70o
C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Kinase Assay, Western Blot
: ~71 kDa
: MGC117401; MGC138280; MGC142070
: VRK1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. VRK1 is widely expressed in human tissues and actively dividing cells, such as those in testis, leukocytes, fetal liver and carcinomas. VRK1 regulate cell proliferation and phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. The spinal muscular atrophy with pontocerebellar hypoplasia is caused by a mutation in the VRK1 gene.
1. Nezu, J. et.al: Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase. Genomics 45: 327-331, 1997.
2. Renbaum, P. et.al: Spinal muscular atrophy with pontocerebellar hypoplasia is caused by a mutation in the VRK1 gene. Am. J. Hum. Genet. 85: 281-289, 2009.
||Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
The VRK1, Active product can be utilized in the following research areas, but not limited to:
Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases