DNMT3L Protein Signaling Proteins Acetyl/Methyltransferase Proteins


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DNMT3L Protein (D353-30CG)
Catalog Number Pack Size Price (USD)  
DNMT3L Protein D353-30CG-20 20 ug $195 DNMT3L Protein  40% OFF   DNMT3L Protein Add to Cart
DNMT3L Protein D353-30CG-50 50 ug $395 DNMT3L Protein  40% OFF   DNMT3L Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human DNMT3L was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: BC002560
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~70 kDa

Gene Aliases: MGC1090

Scientific Background: DNMT3L is an enzymatically inactive regulatory factor that shares sequence homology with the DNA methyltransferases DNMT3A and DNMT3B. DNMT3L is involved in the establishment of DNA methylation patterns during gametogenesis. In mammals, DNA methylation is used for heritable silencing of retrotransposons and imprinted genes and for inactivation of the X chromosome in females (1). DNMT3L has a genomewide role in CpG island methylation beyond genomic imprinting (2). DNMT3L functions as a regulator of methylation at imprinted loci rather than a DNA cytosine methyltransferase because of a lack of catalytic motifs in its sequence.

References: 
1. Ooi, S. K. T. et.al: DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 448: 714-717, 2007.

2. Smallwood, S. A. et.al: Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nature Genet. 43: 811-814, 2011.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




DNMT3L Protein Research Areas

The DNMT3L Protein product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology



DNMT3L Protein Related Products Found: Total 7 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins DNMT1 Protein D351-31G Western Blot View DNMT1 Protein
Signaling Proteins DNMT3A Protein D353-30G Western Blot View DNMT3A Protein
Signaling Proteins DNMT3B Protein D353-30BG Western Blot View DNMT3B Protein
Signaling Reagents DNMT Substrate-1 New Signaling Reagents D53-58 DNA methyltransferase assay (50pmole per reaction). View DNMT Substrate-1
Enzymes DNMT3A, Active New Enzymes D353-380G Methyltransferase Assay View DNMT3A, Active
Enzymes DNMT3B, Active New Enzymes D353-380BG Methyltransferase Assay View DNMT3B, Active
Enzymes DNMT3L, Active New Enzymes D353-380CG Methyltransferase Assay View DNMT3L, Active


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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