CyclinD1 Protein Signaling Proteins Cell Cycle Proteins


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CyclinD1 Protein (C81-30G)
Catalog Number Pack Size Price (USD)  
CyclinD1 Protein C81-30G-20 20 ug $195 CyclinD1 Protein  40% OFF   CyclinD1 Protein Add to Cart
CyclinD1 Protein C81-30G-50 50 ug $395 CyclinD1 Protein  40% OFF   CyclinD1 Protein Add to Cart
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Bulk Pricing for CyclinD1 Protein

Product Data Sheet(s)




Description: Recombinant full-length human CyclinD1 was expressed in E. coli cells using an N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Human
Sequence: Full length
Genbank Number: NM_053056
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~61kDa

Gene Aliases : BCL1, PRAD1, U21B31, D11S287E

Scientific Background: CyclinD1 is a member of the cyclin family of proteins that are important regulators cyclin-dependent protein kinases (CDKs) (1). CyclinD1 forms a complex and functions as a regulatory subunit of CDK4 or CDK6 which are important during cell cycle G1/S transition. CyclinD1 has been shown to interact with the tumor suppressor protein Rb and the expression of CyclinD1 is positively regulated by Rb. Mutations, amplification and overexpression of CyclinD1 have been frequently observed in a variety of tumors and suggesting a role of this protein in tumorigenesis (2).

References: 
1. Fu, M. et al: Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 145: 5439-5447, 2004.

2. Lamb, J. Et al: A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer. Cell 114: 323-334, 2003



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




CyclinD1 Protein Research Areas

The CyclinD1 Protein product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle



CyclinD1 Protein Related Products Found: Total 15 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes CDK4/CyclinD1, Active C31-10G Kinase Assay, Western Blot View CDK4/CyclinD1, Active
Signaling Proteins p18INK4C Protein C32-30G Kinase Assay, Western Blot View p18INK4C Protein
Signaling Proteins p19INK4D Protein C33-30G Kinase Assay, Western Blot View p19INK4D Protein
Enzymes GSK3 beta, Active G09-10H Kinase Assay, Western Blot View GSK3 beta, Active
Signaling Proteins GSK3 beta, Unactive G09-14G Kinase Assay, Western Blot View GSK3 beta, Unactive
Enzymes GSK3 beta, Active G09-10G Kinase Assay, Western Blot View GSK3 beta, Active
Signaling Proteins CyclinA2 Protein C78-30BG Western Blot View CyclinA2 Protein
Signaling Proteins CyclinK Protein C84-30G Kinase Assay, Western Blot View CyclinK Protein
Signaling Proteins CDK5P25 Protein C34-31G Kinase Assay, Western Blot View CDK5P25 Protein
Signaling Proteins CyclinE1 Protein C82-30G Kinase Assay, Western Blot View CyclinE1 Protein
Signaling Proteins CyclinD1 Protein C81-30BG Kinase Assay, Western Blot View CyclinD1 Protein
Signaling Proteins CyclinC Protein C80-30G Western Blot View CyclinC Protein
Signaling Proteins CyclinH Protein New Signaling Proteins C83-30H Western Blot View CyclinH Protein
Signaling Proteins CyclinO Protein New Signaling Proteins C85-30G Western Blot View CyclinO Protein
Signaling Proteins CyclinY Protein New Signaling Proteins C87-30G Western Blot View CyclinY Protein


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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