p18INK4C Protein Signaling Proteins Cell Cycle Proteins


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p18INK4C Protein (C32-30G)
Catalog Number Pack Size Price (USD)  
p18INK4C Protein C32-30G-20 20 ug $195 p18INK4C Protein  40% OFF   p18INK4C Protein Add to Cart
p18INK4C Protein C32-30G-50 50 ug $395 p18INK4C Protein  40% OFF   p18INK4C Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human p18INK4C was expressed in E. coli cells using an N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Human
Sequence: Full length
Genbank Number: NM_001262
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~42 kDa

Gene Aliases: CDKN2C, p18, INK4C, p18-INK4C

Scientific Background: p18INK4C is a member of the INK4 family of proteins that regulate the G1 to S cell cycle transition by binding to and inhibiting the pRb kinase activity of cyclin-dependent kinases 4 and 6 (1). Mutation of p18INK4C impairs B-cell terminal differentiation and confers increased susceptibility to tumor development. p18INK4C can function as a tumor suppressor gene in Hodgkins lymphoma and its inactivation may contribute to the cell cycle deregulation and defective terminal differentiation characteristic of the Reed-Sternberg cells (2).

References: 
1. Ravichandran, N. et al: Structure-based Design of p18INK4c Proteins with Increased Thermodynamic Stability and Cell Cycle Inhibitory Activity. J. Biol. Chem., 2002; 277: 48827-48833.

2. Sánchez-Aguilera,A. et al: Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. Blood. 2004;103(6):2351-7.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




p18INK4C Protein Research Areas

The p18INK4C Protein product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle



p18INK4C Protein Related Products Found: Total 43 Related Products
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Enzymes ABL1, Active A03-18H Kinase Assay, Western Blot View ABL1, Active
Enzymes ABL2, Active A04-11H Kinase Assay, Western Blot View ABL2, Active
Signaling Proteins BCR Protein B01-35G Western Blot View BCR Protein
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Enzymes CDK4/CyclinD1, Active C31-10G Kinase Assay, Western Blot View CDK4/CyclinD1, Active
Signaling Proteins CDK4, Unactive C31-14G Kinase Assay, Western Blot View CDK4, Unactive
Enzymes CDK5/p25, Active C33-10G Kinase Assay, Western Blot View CDK5/p25, Active
Signaling Proteins CDK5, Unactive C33-14G Kinase Assay, Western Blot View CDK5, Unactive
Enzymes CDK7/Cyclin H1/MNAT1, Active C36-10H Kinase Assay, Western Blot View CDK7/Cyclin H1/MNAT1, Active
Enzymes CDK9/CyclinK, Active C40-10G Kinase Assay, Western Blot View CDK9/CyclinK, Active
Enzymes CLK1, Active C57-11G Kinase Assay, Western Blot View CLK1, Active
Enzymes CLK2, Active C58-11G Kinase Assay, Western Blot View CLK2, Active
Signaling Proteins LATS2, Unactive L02-35G Kinase Assay, Western Blot View LATS2, Unactive
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Signaling Reagents Rb (C-Term) Protein R05-55G Kinase Assay, Western Blot View Rb (C-Term) Protein
Signaling Reagents Rb (N-Term) Protein R05-56G Kinase Assay, Western Blot View Rb (N-Term) Protein
Signaling Proteins Tau-352 Protein T03-54N Kinase Assay, Western Blot View Tau-352 Protein
Signaling Proteins Tau-381 Protein T04-54N Kinase Assay, Western Blot View Tau-381 Protein
Signaling Proteins Tau-383 Protein T05-54N Kinase Assay, Western Blot View Tau-383 Protein
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Signaling Proteins Tau-412 Protein T07-54N Kinase Assay, Western Blot View Tau-412 Protein
Signaling Proteins Tau-441 Protein T08-54N Kinase Assay, Western Blot View Tau-441 Protein
Enzymes TAOK1, Active T24-11G Kinase Assay, Western Blot View TAOK1, Active
Enzymes TAOK2, Active T25-11G Kinase Assay, Western Blot View TAOK2, Active
Signaling Proteins p19INK4D Protein C33-30G Kinase Assay, Western Blot View p19INK4D Protein
Enzymes CDK3/CyclinE1, Active C30-10G Kinase Assay, Western Blot View CDK3/CyclinE1, Active
Enzymes CDK4/CyclinD3, Active C31-18G Kinase Assay, Western Blot View CDK4/CyclinD3, Active
Signaling Proteins CyclinD1 Protein C81-30G Kinase Assay, Western Blot View CyclinD1 Protein
Enzymes CDK6/CyclinD1, Active C35-18H Kinase Assay, Western Blot View CDK6/CyclinD1, Active
Signaling Proteins CDK2/CyclinE1, Unactive C29-14G Kinase Assay, Western Blot View CDK2/CyclinE1, Unactive
Enzymes CDC7/DBF4, Active C26-10G Kinase Assay, Western Blot View CDC7/DBF4, Active
Signaling Proteins CDC7 Protein C26-30G Western Blot View CDC7 Protein
Signaling Proteins CDK3, Unactive C30-14G Kinase Assay, Western Blot View CDK3, Unactive
Signaling Proteins CDK2, Unactive C29-14BG Kinase Assay, Western Blot View CDK2, Unactive
Signaling Proteins CDK4, Unactive C31-14BG Kinase Assay, Western Blot View CDK4, Unactive
Signaling Proteins CDK7, Unactive C36-14G Kinase Assay, Western Blot View CDK7, Unactive
Signaling Proteins CDK11, Unactive C42-14G Kinase Assay, Western Blot View CDK11, Unactive


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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