p21CIP1 Protein Signaling Proteins Cell Cycle Proteins


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p21CIP1 Protein (C27-30G)
Catalog Number Pack Size Price (USD)  
p21CIP1 Protein C27-30G-20 20 ug $195 p21CIP1 Protein  40% OFF   p21CIP1 Protein Add to Cart
p21CIP1 Protein C27-30G-50 50 ug $395 p21CIP1 Protein  40% OFF   p21CIP1 Protein Add to Cart
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Bulk Pricing for p21CIP1 Protein

Product Data Sheet(s)




Description: Recombinant full-length human p21CIP1 was expressed in E. coli cells using a N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Human
Sequence: Full length
Genbank Number: NM_000389
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~46 kDa

Gene Aliases: CDKN1A, P21, SDI1, WAF1, CAP20, CDKN1, MDA-6

Scientific Background: CIP 1 (Cyclin-Dependent Kinase Inhibitor 1A) regulates cell cycle progression, terminal differentiation, and apoptosis (1). CIP1 was shown to be induced by p53 and to be a potent inhibitor of cyclin-dependent kinase (CDK) activity. DNA damage leads to increased expression of CIP1 in cyclin E-containing complexes and to an associated decrease in cyclin-dependent kinase activity. CIP1 is a critical downstream effector in the p53-specific pathway of growth control in mammalian cells (2).

References: 
1. el-Deiry, W S. et al: WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 1994;54(5):1169-74

2. Wagner, M. et al: Cyclin-dependent kinase-inhibitor 1 (CDKN1A) in the squamous epithelium of the oropharynx: possible implications of molecular biology and compartmentation. Anticancer Res. 2001; 21(1A):333-45.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




p21CIP1 Protein Research Areas

The p21CIP1 Protein product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle



p21CIP1 Protein Related Products Found: Total 23 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes CDK2/CyclinA2, Active C29-10G Kinase Assay, Western Blot View CDK2/CyclinA2, Active
Enzymes CDK4/CyclinD1, Active C31-10G Kinase Assay, Western Blot View CDK4/CyclinD1, Active
Signaling Proteins p53 Protein P05-30G Kinase Assay, Western Blot View p53 Protein
Enzymes CDK5/p25, Active C33-10G Kinase Assay, Western Blot View CDK5/p25, Active
Signaling Proteins p53 Protein P05-30BG Kinase Assay, Western Blot View p53 Protein
Enzymes CDK1/CyclinA2, Active C22-18G Kinase Assay, Western Blot View CDK1/CyclinA2, Active
Enzymes CDK7/CyclinH1/MNAT1, Active C36-10H Kinase Assay, Western Blot View CDK7/CyclinH1/MNAT1, Active
Signaling Proteins p18INK4C Protein C32-30G Kinase Assay, Western Blot View p18INK4C Protein
Signaling Proteins p19INK4D Protein C33-30G Kinase Assay, Western Blot View p19INK4D Protein
Enzymes CDK4/CyclinD3, Active C31-18G Kinase Assay, Western Blot View CDK4/CyclinD3, Active
Enzymes CDK3/CyclinE1, Active C30-10G Kinase Assay, Western Blot View CDK3/CyclinE1, Active
Enzymes CDK6/CyclinD3, Active C35-10H Kinase Assay, Western Blot View CDK6/CyclinD3, Active
Enzymes CDK2/CyclinE1, Active C29-18G Kinase Assay, Western Blot View CDK2/CyclinE1, Active
Signaling Proteins CDK2/CyclinE1, Unactive C29-14G Kinase Assay, Western Blot View CDK2/CyclinE1, Unactive
Antibodies Anti-p21CIP1 C27-63R WB View Anti-p21CIP1
Enzymes CDC7/DBF4, Active C26-10G Kinase Assay, Western Blot View CDC7/DBF4, Active
Enzymes NDR2, Active S50-10G Kinase Assay, Western Blot View NDR2, Active
Signaling Proteins CDC7 Protein C26-30G Western Blot View CDC7 Protein
Signaling Proteins CDK3, Unactive C30-14G Kinase Assay, Western Blot View CDK3, Unactive
Signaling Proteins CDK2, Unactive C29-14BG Kinase Assay, Western Blot View CDK2, Unactive
Signaling Proteins CDK4, Unactive C31-14BG Kinase Assay, Western Blot View CDK4, Unactive
Signaling Proteins CDK7, Unactive C36-14G Kinase Assay, Western Blot View CDK7, Unactive
Signaling Proteins CDK11, Unactive C42-14G Kinase Assay, Western Blot View CDK11, Unactive


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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