Description: Full-length recombinant human p73 gamma was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.

Storage, Stability, and Shipping: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~85 kDa

Gene Aliases: TP73, TAp73gamma

Scientific Background: p73γ is a member of the p53 family of transcription factors which are involved in cellular responses to stress and development. There are four isoforms of p73 (p73α, p73β, p73δ and p73γ) which differed in their abilities to form homodimeric and heterodimeric interactions with each other and with p53 (1). The p73 isoforms also differed in their abilities to activate transcription of the p21(Waf1) promoter and to inhibit colony formation. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. p73 is a stress-response gene that activates transcription of p53-responsive genes and inhibits cell growth in a p53-like manner by inducing apoptosis (2).

References: 
1. De Laurenzi, V. et al: Two new p73 splice variants, gamma and delta, with different transcriptional activity. J. Exp. Med. 188: 1763-1768, 1998.

2. Jost. C. A. et.al: p73 is a human p53-related protein that can induce apoptosis. Nature 389: 191-194, 1997.

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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