Description: Recombinant full-length human tag-free 14-3-3zeta was expressed in E. coli cells.

Storage, Stability, and Shipping: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~29kDa

Gene Aliases : 14-3-3 zeta, YWHAZ, KCIP-1, MGC111427, MGC126532, MGC138156

Scientific Background: 14-3-3ζ (also known as tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3ζ protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis (1). 14-3-3ζ protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (2).

References: 
1. Li, Z. et al: Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation.Proc NatlAcadSci U S A. 2008; 105(1):162-7.

2. Niemantsverdriet, M. et al: Cellular functions of 14-3-3 zeta in apoptosis and cell adhesion emphasize its oncogenic character.Oncogene. 2008;27(9):1315-9. 2007

		Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.

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