Storage, Stability, and Shipping
: Store product at –70o
C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Western Blot
: UBB, MGC8385, FLJ25987
: Ubiquitin is a highly-conserved protein that is widely expressed in eukaryotes (1). Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal and normal proteins with a rapid turnover. A mutant form of ubiquitin, UBB+1,accumulates in the pathological hallmarks of tauopathies, including Alzheimer's disease, polyglutamine diseases, liver disease and muscle disease and serves as an endogenous reporter for proteasomal dysfunction in these diseases. By inhibiting the proteasome machinery, UBB+1 is pathogenic, since it promotes accumulation of cytotoxic misfolded amyloid-beta and phosphorylated-tau (2).
1. Baker, R T. et al: The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily. Nucleic Acids Res.15: 443-463, 1987.
2. Fratta, P. et al: Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers.Neurology. 2004 Sep 28;63(6):1114-7.
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
The Ubiquitin Protein product can be utilized in the following research areas, but not limited to:
Angiogenesis, Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Inflammation, Invasion/Metastasis, Neurobiology