Ubiquitin Protein Signaling Proteins Ubiquitin Proteins


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Ubiquitin Protein (U06-54H)
Catalog Number Pack Size Price (USD)  
Ubiquitin Protein U06-54H-20 20 ug $195 Ubiquitin Protein  40% OFF   Ubiquitin Protein Add to Cart
Ubiquitin Protein U06-54H-50 50 ug $395 Ubiquitin Protein  40% OFF   Ubiquitin Protein Add to Cart
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Product Data Sheet(s)




Description: Recombinant human Ubiquitin (1-76) protein was expressed in E. coli cells using an N-terminal His tag.
Tag: His tag
Expression System: E.coli
Species: Human
Sequence: 1-76
Genbank Number: NM_018955
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~10kDa

Gene Aliases : UBB, MGC8385, FLJ25987

Scientific Background: Ubiquitin is a highly-conserved protein that is widely expressed in eukaryotes (1). Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal and normal proteins with a rapid turnover. A mutant form of ubiquitin, UBB+1,accumulates in the pathological hallmarks of tauopathies, including Alzheimer's disease, polyglutamine diseases, liver disease and muscle disease and serves as an endogenous reporter for proteasomal dysfunction in these diseases. By inhibiting the proteasome machinery, UBB+1 is pathogenic, since it promotes accumulation of cytotoxic misfolded amyloid-beta and phosphorylated-tau (2).

References: 
1. Baker, R T. et al: The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily. Nucleic Acids Res.15: 443-463, 1987.

2. Fratta, P. et al: Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers.Neurology. 2004 Sep 28;63(6):1114-7.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




Ubiquitin Protein Research Areas

The Ubiquitin Protein product can be utilized in the following research areas, but not limited to:

Angiogenesis, Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Inflammation, Invasion/Metastasis, Neurobiology



Ubiquitin Protein Related Products Found: Total 9 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes AKT1, Active A16-10G Kinase Assay, Western Blot View AKT1, Active
Signaling Proteins AKT1, Unactive A16-14G Kinase Assay, Western Blot View AKT1, Unactive
Signaling Proteins IkBA Protein I20-30G Kinase Assay, Western Blot View IkBA Protein
Signaling Proteins IkBA Protein I20-31G Kinase Assay, Western Blot View IkBA Protein
Signaling Proteins IkBB Protein I21-30G Kinase Assay, Western Blot View IkBB Protein
Enzymes WNK1, Active W02-11G Kinase Assay, Western Blot View WNK1, Active
Signaling Proteins UBA2 (SAE2) Protein U202-30G Western Blot View UBA2 (SAE2) Protein
Signaling Proteins UBA3 (UBE1C) Protein U203-30G Western Blot View UBA3 (UBE1C) Protein
Signaling Proteins UBLE1A (SAE1) Protein U208-30G Western Blot View UBLE1A (SAE1) Protein


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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