Storage, Stability, and Shipping
: Store product at -70o
C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
: Western Blot
: ~100 kDa
: AOF2; BHC110; LSD1; KIAA0601
: KDM1A or lysine (K)-specific demethylase 1A is a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain that is a component of several histone deacetylase complexes and act as a histone demethylase. (1) H3K4 histone demethylase activity of KDM1A is partly responsible for the repressive activity of TAL1 and restricts TAL1 function in hematopoiesis (1). KDM1A plays an essential role for CoREST in demethylation of H3K4 both in vitro and in vivo (2).
1. Hu, X. et.al : LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Nat. Acad. Sci. 106: 10141-10146, 2009.
2. Lee, M. G. et.al : An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 437: 432-435, 2005
||Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
The KDM1A Protein product can be utilized in the following research areas, but not limited to:
Cancer, Cell Cycle, Inflammation