Storage, Stability, and Shipping: Store product at –70
oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications: Western Blot
Molecular Weight: ~21 kDa
Gene Aliases: UBC7; E217K; UBE2G
Scientific Background: UBE2G1 (UBC7) or ubiquitin-conjugating enzyme E2G 1 is a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins which are involved in degradation of muscle-specific proteins. UBC7 is highly expressed in skeletal muscle (1). UBC7 is involved in the selective ubiquitylation of different substrates by the same E3 complex (2).
References:
1. Watanabe, T. K. et.al: Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. Cytogenet. Cell Genet. 74: 146-148, 1996.
2. Shibata E. et.al: Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. Mol Cell Biol, 2011 Aug.
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Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet. |
The UBE2G1 (UBC7) Protein product can be utilized in the following research areas, but not limited to:
Cancer, Cell Cycle, Cytoplasmic Tyrosine Kinases, Neurobiology