JNK1 Unactive Signaling Proteins Unactive Kinases


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JNK1, Unactive (M33-14G)
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JNK1, Unactive M33-14G-20 20 ug $195 JNK1, Unactive  40% OFF   JNK1, Unactive Add to Cart
JNK1, Unactive M33-14G-50 50 ug $395 JNK1, Unactive  40% OFF   JNK1, Unactive Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length mouse JNK1 was expressed in E. coli cells using an N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Mouse
Sequence: Full length
Genbank Number: NM_016700
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~70 kDa

Gene Aliases : JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2

Scientific Background: JNK1 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. JNK1 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK1 has been shown to play an important role in disease processes. Activation of JNK1 results in defects in myotube viability and integrity leading to dystrophic myofiber destruction (2). JNK1 activity is also abnormally elevated in obesity and removal of JNK1 results in decreased adiposity and significantly improved insulin sensitivity.

References: 
1. Derijard, B. et al: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 1994 Mar 25;76(6):1025-37.

2. Kolodziejczyk, S M. et al: Activation of JNK1 contributes to dystrophic muscle pathogenesis. Curr Biol. 2001 Aug 21;11(16):1278-82.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




JNK1, Unactive Research Areas

The JNK1, Unactive product can be utilized in the following research areas, but not limited to:

Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, JNK/SAPK Pathway, Neurobiology, NfkB Pathway, Ser/Thr Kinases



JNK1, Unactive Related Products Found: Total 32 Related Products
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Signaling Proteins JNK3, Unactive M35-14G Kinase Assay, Western Blot View JNK3, Unactive
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Enzymes TAOK1, Active T24-11G Kinase Assay, Western Blot View TAOK1, Active
Enzymes TAOK2, Active T25-11G Kinase Assay, Western Blot View TAOK2, Active
Signaling Proteins Tau-352 Protein T03-54N Kinase Assay, Western Blot View Tau-352 Protein
Signaling Proteins Tau-381 Protein T04-54N Kinase Assay, Western Blot View Tau-381 Protein
Signaling Proteins Tau-383 Protein T05-54N Kinase Assay, Western Blot View Tau-383 Protein
Signaling Proteins Tau-410 Protein T06-54N Kinase Assay, Western Blot View Tau-410 Protein
Signaling Proteins Tau-412 Protein T07-54N Kinase Assay, Western Blot View Tau-412 Protein
Signaling Proteins Tau-441 Protein T08-54N Kinase Assay, Western Blot View Tau-441 Protein
Enzymes HIPK4, Active H06-10G Kinase Assay, Western Blot View HIPK4, Active
Enzymes AMPK (A1/B1/G3), Active P56-10H Kinase Assay, Western Blot View AMPK (A1/B1/G3), Active
Enzymes AMPK (A1/B2/G1), Active P50-10H Kinase Assay, Western Blot View AMPK (A1/B2/G1), Active
Enzymes MEKK2, Active M10-10G Kinase Assay, Western Blot View MEKK2, Active
Enzymes MEKK3, Active M11-10G Kinase Assay, Western Blot View MEKK3, Active
Signaling Proteins TRAF2 Protein T57-30H Western Blot View TRAF2 Protein
Antibodies Anti-JNK1 M33-63R WB View Anti-JNK1
Enzymes JNK2, Active M34-10BG Kinase Assay, Western Blot View JNK2, Active
Enzymes JNK3, Active M35-10BG Kinase Assay, Western Blot View JNK3, Active


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
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Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
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Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
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Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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