PAK1 Unactive Signaling Proteins Unactive Kinases


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PAK1, Unactive (P02-14G)
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PAK1, Unactive P02-14G-20 20 ug $195 PAK1, Unactive  40% OFF   PAK1, Unactive Add to Cart
PAK1, Unactive P02-14G-50 50 ug $395 PAK1, Unactive  40% OFF   PAK1, Unactive Add to Cart
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Product Data Sheet(s)




Description: Recombinant full-length human PAK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Cannot be activated by CDC42.
Tag: GST tag
Expression System: Sf9 insect cells using baculovirus
Species: Human
Sequence: Full length
Genbank Number: BC050377
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Western Blot

Molecular Weight: ~88 kDa

Gene Aliases: PAKalpha; MGC130000; MGC130001

Scientific Background: PAK1 is a member of the p21-activated kinases (PAKs) which have been implicated in the regulation of cell morphology, motility and transformation. These serine/threonine kinases are activated by and are effectors of small GTPases, cdc 42 and Rac. PAK1 belongs to the Group I PAKs which also includes PAK2 and PAK3 (1). Pak1 is a key regulator of the actin cytoskeleton, adhesion and cell motility. Inactive dimeric Pak1 is mainly cytosolic and interaction with the activators Cdc42-GTP and Rac1-GTP stimulates the kinase at the sites of cellular protrusions forming adhesions to the extracellular matrix (2).

References: 
1. Jaffer, Z M. et al: p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol. 2002 Jul;34(7):713-7.

2. Parrini, M C. et al: Spatiotemporal regulation of the Pak1 kinase. Biochem Soc Trans. 2005 Aug;33(Pt 4):646-8.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




PAK1, Unactive Research Areas

The PAK1, Unactive product can be utilized in the following research areas, but not limited to:

Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases



PAK1, Unactive Related Products Found: Total 9 Related Products
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Antibodies Anti-PAK1 P02-63R WB View Anti-PAK1
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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
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Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
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Signaling Proteins
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Signaling Proteins Arginine Deiminases Arginine Deiminases
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Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
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Signaling Proteins Unactive Kinases Unactive Kinases
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Discovery Services
Compound Selective Profiling Compound Selective Profiling
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Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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