MEK1 (K97A) Unactive Signaling Reagents Protein Substrates


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MEK1 (K97A), Unactive (M02-16H)
Catalog Number Pack Size Price (USD)  
MEK1 (K97A), Unactive M02-16H-20 20 ug $195   MEK1 (K97A), Unactive Add to Cart
MEK1 (K97A), Unactive M02-16H-50 50 ug $395   MEK1 (K97A), Unactive Add to Cart
MEK1 (K97A), Unactive M02-16H-BULK BULK CONTACT US  
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Product Data Sheet(s)




Description: Recombinant human full-length mutant MEK1 (K97A) was expressed by E. coli using an N-terminal His tag. This kinase-dead protein is designed for up-stream kinase assay.
Tag: His tag
Expression System: E.coli
Species: Human
Sequence: Full length
Genbank Number: NM_002755
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~49 kDa

Gene Aliases: MAP2K1, MKK1, MAPKK1, PRKMK1

Scientific Background: MEK1 is a member of the dual specificity protein kinase family that acts as a mitogen-activated protein kinase (MAPK) kinase. MEK1 lies upstream of MAPK/ERK and stimulates the enzymatic activity of MAPK/ERK upon a wide variety of extra- and intracellular signals. As an essential component of MAPK/ERK signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development (1). Constitutive activation of MEK1 results in cellular transformation. Thus, MEK1 represents a likely target for pharmacologic intervention in proliferative disease such as cancer (2).

References: 
1. Seger, R. et al: The MAPK signaling cascade. FASEB J. 9: 726-735, 1995.

2. Sebolt-Leopold, J S. et al: Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nature Med. 5: 810-816, 1999.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




MEK1 (K97A), Unactive Research Areas

The MEK1 (K97A), Unactive product can be utilized in the following research areas, but not limited to:

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases



MEK1 (K97A), Unactive Related Products Found: Total 12 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Enzymes MEK1, Active M02-10G Kinase Assay, Western Blot View MEK1, Active
Enzymes MEK1 (EE), Active M02-12G Kinase Assay, Western Blot View MEK1 (EE), Active
Signaling Proteins MEK1, Unactive M02-14BG Kinase Assay, Western Blot View MEK1, Unactive
Signaling Proteins MEK1, Unactive M02-14H Kinase Assay, Western Blot View MEK1, Unactive
Antibodies Anti-MEK1 M02-60M WB, IP View Anti-MEK1
Antibodies Anti-MEK1/2 M02-63R WB View Anti-MEK1/2
Enzymes BRAF, Active B08-11G Kinase Assay, Western Blot View BRAF, Active
Enzymes BRAF (V599E), Active B08-13G Kinase Assay, Western Blot View BRAF (V599E), Active
Enzymes MEKK1, Active M09-11G Kinase Assay, Western Blot View MEKK1, Active
Enzymes MEKK2, Active M10-10G Kinase Assay, Western Blot View MEKK2, Active
Enzymes COT, Active M16-11G Kinase Assay, Western Blot View COT, Active
Enzymes RAF1 (EE), Active R01-13G Kinase Assay, Western Blot View RAF1 (EE), Active


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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