Rb (N-Term) Protein Signaling Reagents Protein Substrates


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Rb (N-Term) Protein (R05-56G)
Catalog Number Pack Size Price (USD)  
Rb (N-Term) Protein R05-56G-20 20 ug $195   Rb (N-Term) Protein Add to Cart
Rb (N-Term) Protein R05-56G-50 50 ug $395   Rb (N-Term) Protein Add to Cart
Rb (N-Term) Protein R05-56G-BULK BULK CONTACT US  
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Bulk Pricing for Rb (N-Term) Protein

Product Data Sheet(s)




Description: Recombinant human Rb (48-378) was expressed in E. coli cells using an N-terminal GST tag.
Tag: GST tag
Expression System: E.coli
Species: Human
Sequence: 48-378
Genbank Number: NM_000321
   

Storage, Stability, and Shipping: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay, Western Blot

Molecular Weight: ~62 kDa

Gene Aliases: RB1, OSRC

Scientific Background: Rb is the retinoblastoma gene product and was the first tumor suppressor cloned. Rb is a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase (1). Rb can bind to MDM2 and this overcomes both the antiapoptotic function of MDM2 and the MDM2-dependent degradation of p53. Rb associates with the Polycomb group (PcG) proteins to form a repressor complex that blocks entry of cells into mitosis (2). Rb colocalizes with nuclear PcG complexes and is important for association of PcG complexes with nuclear targets.

References: 
1. Hanahan, D.et al: The hallmarks of cancer. Cell 100: 57-70, 2000.

2. Dahiya, A. et al: Linking the Rb and Polycomb pathways. Molec. Cell 8: 557-568, 2001.



  Purity:  Sample Purity Data. For specific information on a given lot, see related technical data sheet.




Rb (N-Term) Protein Research Areas

The Rb (N-Term) Protein product can be utilized in the following research areas, but not limited to:

Cancer, Cell Cycle, Neurobiology



Rb (N-Term) Protein Related Products Found: Total 16 Related Products
Product Type Product Name Catalog Number Application Pack Sizes
Signaling Proteins p53 Protein P05-30G Kinase Assay, Western Blot View p53 Protein
Enzymes CDK2/CyclinA2, Active C29-10G Kinase Assay, Western Blot View CDK2/CyclinA2, Active
Enzymes CDK5/p25, Active C33-10G Kinase Assay, Western Blot View CDK5/p25, Active
Enzymes CDK4/CyclinD1, Active C31-10G Kinase Assay, Western Blot View CDK4/CyclinD1, Active
Signaling Reagents Rb (C-Term) Protein R05-55G Kinase Assay, Western Blot View Rb (C-Term) Protein
Signaling Proteins p53 Protein P05-30BG Kinase Assay, Western Blot View p53 Protein
Enzymes CDK1/CyclinA2, Active C22-18G Kinase Assay, Western Blot View CDK1/CyclinA2, Active
Enzymes CDK7/Cyclin H1/MNAT1, Active C36-10H Kinase Assay, Western Blot View CDK7/Cyclin H1/MNAT1, Active
Signaling Proteins MDM2 Protein M45-31G Western Blot View MDM2 Protein
Signaling Proteins p18INK4C Protein C32-30G Kinase Assay, Western Blot View p18INK4C Protein
Enzymes CDK3/CyclinE1, Active C30-10G Kinase Assay, Western Blot View CDK3/CyclinE1, Active
Enzymes CDK6/CyclinD3, Active C35-10H Kinase Assay, Western Blot View CDK6/CyclinD3, Active
Enzymes CDK4/CyclinD3, Active C31-18G Kinase Assay, Western Blot View CDK4/CyclinD3, Active
Signaling Proteins CDK6, Unactive C35-15H Kinase Assay, Western Blot View CDK6, Unactive
Enzymes CDK2/CyclinE1, Active C29-18G Kinase Assay, Western Blot View CDK2/CyclinE1, Active
Enzymes CDK6/CyclinD1, Active C35-18H Kinase Assay, Western Blot View CDK6/CyclinD1, Active


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Product Types
Enzymes
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinases Active Kinases
Enzymes Active Methyltransferase Active Methyltransferase
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferase Proteins Acetyl/Methyltransferase Proteins
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylase Proteins Deacetylase/Demethylase Proteins
Signaling Proteins Fructose Kinase Proteins Fructose Kinase Proteins
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Lysyl Oxidase Proteins Lysyl Oxidase Proteins
Signaling Proteins Methylcytosine Dioxygenase Proteins Methylcytosine Dioxygenase Proteins
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Antibodies
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Discovery Services
Compound Selective Profiling Compound Selective Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling




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