Key Features and Benefits

High Signal-to-Noise Ratio = Greater Confidence in Your Results

Assays Performed In Triplicate = Statistically Relevant Results

2-week Turnaround Time = Efficiency in the Discovery Process


Screening Highlights

SignalChem's compound selectivity profiling service utilizes a large and diverse panel of highly active protein kinase, phosphatase, phosphodiesterase and histone deactylase enzyme targets that are produced in our manufacturing facility. SignalChem's active enzyme targets are subjected to rigorous quality control analyses and are extensively assayed against a panel of biologically relevant substrates ensuring that all reactions are performed under optimal assay conditions.

SignalChem's compound selectivity profiling service determines the respective inhibitory profile and the putative mechanism of action. All compounds are profiled against a panel of targets either using an individual dose, a single concentration or at multiple concentrations in order to allow in-depth IC₅₀ determinations. In addition, the protein kinase assays can be performed under varying ATP concentrations to evaluate the competitive effects of ATP.

The compound selectivity profiling service offered by SignalChem is a very economical and convenient approach to the drug discovery continuum with a two-week turnaround of your specific profiling results. Compounds can be supplied by the client as DMSO stocks of known concentration, as solid material in vials, or in 96-well plates.

SignalChem Targets

SignalChem produces a diverse and ever-expanding range of targets that are actively being pursued from a drug development perspective, with a main focus on signaling proteins including active protein kinases and phosphatases.

SignalChem's highly purified active enzymes are generated from the full-length human genes and are mutation free. These targets do not harbor any activating mutations, as it is well established that these mutations do not occur in vivo in the disease state.



Restrictions

JAK2*: Patent restrictions on this product exclude it as a profiling target for US customers.

Background

The selectivity profile of any small molecule is of fundamental clinical importance as part of the drug development process. The information yielded from these studies will undoubtedly provide useful insight into the proposed mechanism of action of a given compound as well as leading to the identification of "off" target effects, thus leading to the selection of better lead candidates.

Confidentiality

SignalChem maintains all information under the strictest confidentiality. All information and or materials supplied by the customer will be used as directed by the client. Upon completion of the project, all materials will be either returned to the client or disposed of accordingly. SignalChem is willing to execute confidentiality agreements with its clients.

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