Discovery Services Custom Protein Development: HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC5 HDAC7 HDAC8 HDAC9 SIRT1 SIRT2 SIRT5

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SignalChem's Custom Protein Development

Key Features and Benefits

Expertise in Protein Development = Reliability in Your Results

Targets Highly Characterized = Greater Confidence in Your Results

8 - 12 Weeks Turnaround Time = Efficiency in the Discovery Process

Custom Protein Development Highlights

SignalChem scientist's have gained an extensive experience in the cloning, expression, purification and activation of cellular signaling proteins including protein kinases, protein phosphatases and cellular protein substrates, amongst others.

Depending upon the client's needs, SignalChem scientists will work with you to custom develop the target to your desired specifications within a realistic and suitable timeframe.

Highlights of SignalChem's custom protein development capabilities include:

Production of the full-length or truncated form of the desired target
Production of a highly purified protein
Production of the target as either untagged or tagged protein
Production of the target with high biological activity
Production of proteins from µg to mg scale

SignalChem scientist's can undertake development of a custom protein for a client by adopting a step-wise strategy.

Step 1. Cloning of Target Gene
Based on the target gene, SignalChem scientists will design specific primers against the target of interest and amplify the gene product from cDNA libraries derived from various human cell lines.

Step 2. Sub-Cloning of Target Gene
The cloned target gene is subsequently cloned into the appropriate expression vectors to maximize the expression levels of the desired target.

Step 3. Expression of Desired Protein
Based upon the respective needs of the client, SignalChem scientist will recommend the most suitable expression system to use and as a part of the custom project. The choice of the cells and the expression systems is governed by the level of post-translational modification required and whether enzymatic activity is essential.

Step 4. Purification and Characterization of Target Protein
In the final stages of development, the selected target is purified from the cellular lysate and evaluated to ensure that the final product meets the specifications set forth by the client.


SignalChem maintains all information under the strictest confidentiality. All information and/or materials supplied by the customer will be used as directed by the client. Upon completion of the project, all materials will be either returned to the client or disposed of accordingly. SignalChem is willing to execute confidentiality agreements with its clients.
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Product Types
Enzymes Active Acetyltransferases Active Acetyltransferases
Enzymes Active Arginine Deiminases Active Arginine Deiminases
Enzymes Active GTPases/ATPases Active GTPases/ATPases
Enzymes Active Histone Deacetylases Active Histone Deacetylases
Enzymes Active Kinase Mutants Active Kinase Mutants
Enzymes Active Kinases Active Kinases
Enzymes Active Lipid Kinases Active Lipid Kinases
Enzymes Active Methyltransferases Active Methyltransferases
Enzymes Active Phosphatases Active Phosphatases
Enzymes Active Phosphodiesterases Active Phosphodiesterases
Enzymes Active Proteases Active Proteases
Antibodies Isoform Specific Antibodies Isoform Specific Antibodies
Antibodies Modification Antibodies Modification Antibodies
Antibodies Phospho Specific Antibodies Phospho Specific Antibodies
Antibodies Primary Antibodies Primary Antibodies
Antibodies Secondary Antibodies Secondary Antibodies
Antibodies Tag Antibodies Tag Antibodies
Biochemical Compounds
Biochemical Compounds Epigenetic Enzyme Activators Epigenetic Enzyme Activators
Biochemical Compounds Epigenetic Enzyme Inhibitors Epigenetic Enzyme Inhibitors
Biochemical Compounds Kinase Activators Kinase Activators
Biochemical Compounds Kinase Inhibitors Kinase Inhibitors
Biochemical Compounds Phosphatase Inhibitors Phosphatase Inhibitors
Biochemical Compounds siRNA Controls siRNA Controls
Biochemical Compounds siRNA Sets siRNA Sets
Signaling Proteins
Signaling Proteins Acetyl/Methyltransferases Acetyl/Methyltransferases
Signaling Proteins Adaptor Proteins Adaptor Proteins
Signaling Proteins Apoptosis Proteins Apoptosis Proteins
Signaling Proteins Arginine Deiminases Arginine Deiminases
Signaling Proteins Cell Cycle Proteins Cell Cycle Proteins
Signaling Proteins Cell Stress & Chaperone Proteins Cell Stress & Chaperone Proteins
Signaling Proteins Cellular Proteins Cellular Proteins
Signaling Proteins Deacetylase/Demethylases Deacetylase/Demethylases
Signaling Proteins Dihydropyrimidinase Dihydropyrimidinase
Signaling Proteins Dioxygenases Dioxygenases
Signaling Proteins Fructose Kinases Fructose Kinases
Signaling Proteins G-Proteins G-Proteins
Signaling Proteins Kinase Mutant Proteins Kinase Mutant Proteins
Signaling Proteins Kinase Protein Kinase Protein
Signaling Proteins Lysyl Oxidases Lysyl Oxidases
Signaling Proteins Microtubule/Actin Associated Proteins Microtubule/Actin Associated Proteins
Signaling Proteins Phospholipase C Proteins Phospholipase C Proteins
Signaling Proteins Superoxide Dismutase Superoxide Dismutase
Signaling Proteins Tau Proteins Tau Proteins
Signaling Proteins Transcription Proteins Transcription Proteins
Signaling Proteins Ubiquitin Proteins Ubiquitin Proteins
Signaling Proteins Unactive Kinases Unactive Kinases
Signaling Reagents
Signaling Reagents Assay Reagents Assay Reagents
Signaling Reagents Lipid Substrates Lipid Substrates
Signaling Reagents Oligo Substrates Oligo Substrates
Signaling Reagents Peptide Substrates Peptide Substrates
Signaling Reagents Protein Substrates Protein Substrates
Extracellular Ligands
Extracellular Ligands Chemokines Chemokines
Extracellular Ligands Cytokines Cytokines
Extracellular Ligands Growth Factors Growth Factors
Discovery Services
Compound Selective Profiling Compound Selectivity Profiling
Custom Protein Development Custom Protein Development

Research Categories
AKT/PKB Pathway AKT/PKB Pathway
Angiogenesis Angiogenesis
Apoptosis/Autophagy Apoptosis/Autophagy
Cancer Cancer
Cardiovascular Disease Cardiovascular Disease
Cell Cycle Cell Cycle
Cellular Stress Cellular Stress
Cytoplasmic Tyrosine Kinases Cytoplasmic Tyrosine Kinases
ERK/MAPK Pathway ERK/MAPK Pathway
Inflammation Inflammation
Invasion/Metastasis Invasion/Metastasis
JAK/STAT Pathway JAK/STAT Pathway
JNK/SAPK Pathway JNK/SAPK Pathway
Lipid Kinases Lipid Kinases
Metabolic Disorder Metabolic Disorder
Neurobiology Neurobiology
NfkB Pathway NfkB Pathway
p38 Pathway p38 Pathway
Phosphatases Phosphatases
Phosphodiesterases Phosphodiesterases
PKA/PKC Pathway PKA/PKC Pathway
Receptor Tyrosine Kinases Receptor Tyrosine Kinases
Ser/Thr Kinases Ser/Thr Kinases
WNT Signaling WNT Signaling

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Discovery Services, Custom Protein Development: HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC5, HDAC7, HDAC8, HDAC9, SIRT1, 	SIRT2, SIRT5   Discovery Services, Custom Protein Development: HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC5, HDAC7, HDAC8, HDAC9, SIRT1, 	SIRT2, SIRT5   Discovery Services, Custom Protein Development: HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC5, HDAC7, HDAC8, HDAC9, SIRT1, 	SIRT2, SIRT5