Histone Deacetylases

Histone Deacetylases

The epigenetic mechanisms entailing acetylation and deacetylation of histone proteins are two critical post-translational modifications. Histone deacetylases (HDACs) are a part of a vast family of epigenetic enzymes playing a crucial role in the gene silencing, which controls the gene expression. Members of HDACs are important cellular tools in the maintenance of chromatin architecture and gene transcription.

HDACs remove the acetyl (O=C-CH3) group from an ε-N-acetyl lysine residue on a histone, which allows the DNA to wrap around histones more tightly, thereby impeding the gene expression process. HDACs play a key role in cellular processes such as cell proliferation, cell cycle regulation, apoptosis, and cell differentiation. Altered expression or mutation in the members of HDACs have been observed in many human diseases such as cancer, inflammation, neuropsychiatry, skeletogenesis, cardiovascular growth and more. Signalchem offers a diverse and comprehensive range of active HDACs to facilitate in vitro studies on epigenetic mechanisms and related human diseases. Our active HDACs and sirtuins have been validated using Promega’s HDAC-GloTM and SIRT-GloTM technology respectively.

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Name Catalog Number
HDAC1, Active H83-30G
HDAC10, Active H92-31G
HDAC11, Active H93-30G
HDAC11, Active H93D-30G
HDAC11, Active H93C-30G
HDAC11, Active H93M-30G
HDAC11, Active H93A-30G
HDAC2, Active H84-30G
HDAC3, Active H85-30G
HDAC3/NCOR2, Active H85-38G
HDAC4, Active H86-31G
HDAC4, Active H86-31BG
HDAC5, Active H87-31G
HDAC6, Active H88-30G
HDAC6, Active H88M-30G
HDAC6, Active H88A-30G
HDAC6, Active H88D-30G
HDAC6, Active H88C-30G
HDAC7, Active H89-31G
HDAC8, Active H90-30H
HDAC8, Active H90-30G
HDAC9, Active H91-31G
SIRT1, Active S35-31H
SIRT1, Active S35-31G
SIRT2, Active S36-30H
SIRT3, Active S37-38G
SIRT5, Active S39-30H
SIRT6, Active S40-31H
SIRT7, Active S41-30H



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