Protein phosphorylation is a reversible post-translational modification carried out by two families of enzymes, Protein Kinases and Protein Phosphatases. The interplay between these two families of enzymes is responsible for modulating the phosphorylation state of their physiological substrates, and thereby their activities, subcellular localization and interactions with other proteins. Similar to Protein Kinases, Protein Phosphatases play pivotal roles in a myriad of biological processes including cell growth, proliferation, survival, and apoptosis. Protein Phosphatases are broadly categorized according to specific amino acids they dephosphorylate into two major families: protein serine/threonine phosphatases, and protein tyrosine phosphatases, which also include the dual-specificity phosphatases.

SignalChem, with comprehensive active Protein Kinase product line, has utilized our expertise in the recombinant protein production to manufacture biologically active phosphatases including PP1s, PP2s, PTPNs, and more. An in-house product development team with over 100 years of combined experience in protein biochemistry is behind the production and quality control of all the phosphatases as well as the method development for their activity assays. We aim to manufacture our phosphatases with superior quality and activity to facilitate and assist the global research and drug discovery efforts aiding human health.

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Browse our Phosphatases

Name Catalog Number
CaMKPase Protein P06-34G
CDC25A, Active C04-20G
CDC25B, Active C04-20BG
CDC25C, Active C04-20CG
DUSP22 (MKPX), Active D22-20G
Lambda Protein Phosphatase L01-20U
PHLPP2 Protein P72-21G
PP1A, Active P13-20G
PP1A, Active P13-20GH
PP1B, Active P14-20G
PP2A alpha/PPP2R1A Complex, Active P16-20BH
PP2Aα/PPP2R1A Complex, Active P16-20BG
PP2Abeta Protein P17-34G
PP2Calpha, Active P02-20G
PP2Calpha, Active P02-20BG
PP2Cgamma, Active P07-20G
PTEN Protein P23-34G
PTEN, Active T03-20H
PTPN1 (PTP1B), Active P28-20G
PTPN11 (SHP2), Active P38-21G
PTPN11 (SHP2), Active P38-20G
PTPN11 (T253M Q257L), Active P38-22G
PTPN12 (PTP-PEST), Active P39-21G
PTPN13 (FAP-1), Active P40-21G
PTPN2 (TC-PTP), Active P29-20G
PTPN6 (SHP1), Active P33-20G
PTPN6 (SHP1), Active P33-20H
PTPN7 (LC-PTP), Active P34-20G
PTPRA (LRP), Active P48-21G
PTPRB, Active P49-21G
PTPRC (CD45), Active P50-21H
PTPRC (CD45), Active P50-21BG
PTPRE, Active P52-21G
PTPRF (LAR), Active P53-21G
PTPRJ (CD148), Active P56-21G
PTPRM (PTP- mu) Protein P58-35G
PTPRS (PTP- sigma), Active P64-21G
SHIP1, Active P08-20G
SHIP2, Active P09-20G
WIP1, Active P04-20G



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