Phosphodiesterases

Phosphodiesterases (PDEs) play a central role in the regulation of various signaling cascades by specifically hydrolyzing the cyclic nucleotides, cAMP, and cGMP into their nucleoside 5’ -– monophosphate form AMP and GMP respectively. Hydrolysis of these nucleotides results in the breakdown of these secondary messengers and the abrogation of downstream signaling. Given the importance of these enzymes in the regulation of cAMP/cGMP signaling, PDEs have been identified as an important class of potential drug targets in diseases such as cancer, neurodegeneration, coronary heart diseases, asthma and more.

Signalchem has successfully manufactured 19 of the 24 phosphodiesterases from the human genome as active enzymes. Our recombinant PDEs are compatible with their substrates cAMP and cGMP and are ready to be included in enzyme activity and inhibitor profiling assays. Our PDEs are tested exclusively using Promega's PDE-Glo™ Assay technology.

Name	Catalog Number	Species	Tag	Expression System	Sequence	Genbank Number
ENPP2, Active	E322-310G	Human	GST	Sf9 insect cells using baculovirus	36-end	BC034961
PDE10A, Active	P98-31G	Human	GST	Sf9 insect cells using baculovirus	71-end	NM_006661
PDE12, Active	P100-310G	Human	GST	Sf9 insect cells using baculovirus	Full length	NM_177966
PDE1A, Active	P89-30H	Human	HIS	Sf9 insect cells using baculovirus	Full Length	NM_005019
PDE1B, Active	P89-30BG	Human	GST	Sf9 insect cells using baculovirus	Full Length	NM_000924
PDE1C, Active	P89-30CG	Human	GST	Sf9 insect cells using baculovirus	Full Length	NM_005020
PDE2A, Active	P90-30G	Human	GST	Sf9 insect cells using baculovirus	Full Length	NM_002599
PDE3A, Active	P91-31G	Human	GST	Sf9 insect cells using baculovirus	669-end	NM_000921
PDE3B, Active	P91-31BG	Human	GST	Sf9 insect cells using baculovirus	654-end	NM_000922
PDE4A, Active	P92-31G	Human	GST	Sf9 insect cells using baculovirus	332-end	NM_001111307
PDE4B, Active	P92-31BG	Human	GST	Sf9 insect cells using baculovirus	305-end	NM_002600
PDE4C, Active	P92-31CG	Human	GST	Sf9 insect cells using baculovirus	287-end	NM_000923
PDE4D, Active	P92-31DG	Human	GST	Sf9 insect cells using baculovirus	225-end	NM_006203
PDE5A, Active	P93-31G	Human	GST	Sf9 insect cells using baculovirus	537-end	NM_001083
PDE6A, Active	P94-31G	Human	GST	Sf9 insect cells using baculovirus	31-end	NM_000440
PDE6B Protein	P94-34BG	Human	GST	Sf9 insect cells using baculovirus	Full length	NM_000283
PDE6C Protein	P94-34CG	Human	GST	Sf9 insect cells using baculovirus	Full Length	BC111377
PDE6D Protein	P94-30DG	Human	GST	Sf9 insect cells using baculovirus	Full length	NM_002601
PDE7A, Active	P95-31G	Human	GST	Sf9 insect cells using baculovirus	104-end	NM_002603
PDE7B, Active	P95-30BG	Human	GST	Sf9 insect cells using baculovirus	Full Length	NM_018945
PDE8A, Active	P96-30G	Human	GST	Sf9 insect cells using baculovirus	Full Length	NM_002605
PDE8B, Active	P96-31BG	Human	GST	Sf9 insect cells using baculovirus	113-end	NM_003719
PDE9A, Active	P97-30G	Human	GST	Sf9 insect cells using baculovirus	Full Length	NM_001001567

Name

Catalog Number

Species

Tag

Expression System

Sequence

Genbank Number

ENPP2, Active

E322-310G

Human

GST

Sf9 insect cells using baculovirus

36-end

BC034961

PDE10A, Active

P98-31G

Human

GST

Sf9 insect cells using baculovirus

71-end

NM_006661

PDE12, Active

P100-310G

Human

GST

Sf9 insect cells using baculovirus

Full length

NM_177966

PDE1A, Active

P89-30H

Human

HIS

Sf9 insect cells using baculovirus

Full Length

NM_005019

PDE1B, Active

P89-30BG

Human

GST

Sf9 insect cells using baculovirus

Full Length

NM_000924

PDE1C, Active

P89-30CG

Human

GST

Sf9 insect cells using baculovirus

Full Length

NM_005020

PDE2A, Active

P90-30G

Human

GST

Sf9 insect cells using baculovirus

Full Length

NM_002599

PDE3A, Active

P91-31G

Human

GST

Sf9 insect cells using baculovirus

669-end

NM_000921

PDE3B, Active

P91-31BG

Human

GST

Sf9 insect cells using baculovirus

654-end

NM_000922

PDE4A, Active

P92-31G

Human

GST

Sf9 insect cells using baculovirus

332-end

NM_001111307

PDE4B, Active

P92-31BG

Human

GST

Sf9 insect cells using baculovirus

305-end

NM_002600

PDE4C, Active

P92-31CG

Human

GST

Sf9 insect cells using baculovirus

287-end

NM_000923

PDE4D, Active

P92-31DG

Human

GST

Sf9 insect cells using baculovirus

225-end

NM_006203

PDE5A, Active

P93-31G

Human

GST

Sf9 insect cells using baculovirus

537-end

NM_001083

PDE6A, Active

P94-31G

Human

GST

Sf9 insect cells using baculovirus

31-end

NM_000440

PDE6B Protein

P94-34BG

Human

GST

Sf9 insect cells using baculovirus

Full length

NM_000283

PDE6C Protein

P94-34CG

Human

GST

Sf9 insect cells using baculovirus

Full Length

BC111377

PDE6D Protein

P94-30DG

Human

GST

Sf9 insect cells using baculovirus

Full length

NM_002601

PDE7A, Active

P95-31G

Human

GST

Sf9 insect cells using baculovirus

104-end

NM_002603

PDE7B, Active

P95-30BG

Human

GST

Sf9 insect cells using baculovirus

Full Length

NM_018945

PDE8A, Active

P96-30G

Human

GST

Sf9 insect cells using baculovirus

Full Length

NM_002605

PDE8B, Active

P96-31BG

Human

GST

Sf9 insect cells using baculovirus

113-end

NM_003719

PDE9A, Active

P97-30G

Human

GST

Sf9 insect cells using baculovirus

Full Length

NM_001001567

Phosphodiesterases

Phosphodiesterases

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