Selective CK2 inhibitor. Inhibits proliferation of Wnt-1 transfected cells and suppresses phosphorylation of beta-catenin. Ameliorates renal dysfunction at 20 mg/Kg in a rat model of glomerulonephritis. Cell permeable and active in vivo.
1. J Shen et al. J. Immunol. 2001 167:4919
2. DH Song et al. J. Biol. Chem. 2000 275:23790
3. M Yamada et al. Proc. Natl. Acad. Sci. USA 2005 102:7736
CAS Registry Number:
>98% (TLC); NMR (Conforms)
May be dissolved in DMSO (50 mg/ml)
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Receptor Tyrosine Kinases, Ser/Thr Kinases, WNT Signaling