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Apigenin

Kinase inhibitor (pan)
Catalog No. K10-900C


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Catalog No. Pack Size Price (USD)
K10-900C-10 10 mg $39
K10-900C-50 50 mg $149
K10-900C-BULK BULK Contact Us  


Overview:

Selective CK2 inhibitor. Inhibits proliferation of Wnt-1 transfected cells and suppresses phosphorylation of beta-catenin. Ameliorates renal dysfunction at 20 mg/Kg in a rat model of glomerulonephritis. Cell permeable and active in vivo.

References:


1. J Shen et al. J. Immunol. 2001 167:4919

2. DH Song et al. J. Biol. Chem. 2000 275:23790

3. M Yamada et al. Proc. Natl. Acad. Sci. USA 2005 102:7736


CAS Registry Number:

520-36-5


Molecular Formula:

C15H10O5


Appearance:

Yellow powder


Melting Point:

345-350oC


Molecular Weight:

270.2


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (50 mg/ml)


Aliases:

4',5,7-Trihydroxyflavone


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Receptor Tyrosine Kinases, Ser/Thr Kinases, WNT Signaling



SIGNALCHEM BIOTECH INC.


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