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Staurosporine

Kinase inhibitor (pan)
Catalog No. K10-900


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Catalog No. Pack Size Price (USD)
K10-900-250 250 ug $259
K10-900-1000 1 mg $457
K10-900-BULK BULK Contact Us  


Overview:

Potent pan-specific protein kinase inhibitor including PKC (IC50= 0.7 nM), PKA (IC50= 7 nM), PKG (IC50= 8.5 nM) and many others. Induces apoptosis in a large variety of cell types. Cell permeable.

References:


1. T Tamaoki et al. Biochem. Biophys. Res. Commun. 1986 135:397

2. H Matsumoto et al. Biochem. Biophys. Res. Commun. 1989 158:105

3. G Preta et al. FEBS Lett. 2012 586:747

4. M Akbar et al. J. Neurochem. 2002 82:655


CAS Registry Number:

62996-74-1


Molecular Formula:

C28H26N4O3


Appearance:

White to yellow powder or lyophilized solid


Melting Point:

N/A


Molecular Weight:

466.50


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in: DMSO (50 mg/ml); or ethanol (2 mg/ml, warm)


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Receptor Tyrosine Kinases, Ser/Thr Kinases, WNT Signaling



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