Potent pan-specific protein kinase inhibitor including PKC (IC50= 0.7 nM), PKA (IC50= 7 nM), PKG (IC50= 8.5 nM) and many others. Induces apoptosis in a large variety of cell types. Cell permeable.
1. T Tamaoki et al. Biochem. Biophys. Res. Commun. 1986 135:397
2. H Matsumoto et al. Biochem. Biophys. Res. Commun. 1989 158:105
3. G Preta et al. FEBS Lett. 2012 586:747
4. M Akbar et al. J. Neurochem. 2002 82:655
CAS Registry Number:
White to yellow powder or lyophilized solid
>98% (TLC); NMR (Conforms)
May be dissolved in: DMSO (50 mg/ml); or ethanol (2 mg/ml, warm)
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Receptor Tyrosine Kinases, Ser/Thr Kinases, WNT Signaling