Potent pan-specific protein kinase inhibitor: PKA (Ki = 90 nM), PKC (Ki = 20 nM), PKG (Ki = 100 nM) (1) as well as other kinases. Cell impermeable (2).
1. H Kase et al. Biochem. Biophys. Res. Commun. 1987 142:436
2. K Makino et al. PLoS One 2012 7:e41049
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White to off-white powder
>98% (TLC); NMR (Conforms)
May be dissolved in DMSO (1 mg/ml); or DMF (1 mg/ml)
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AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Receptor Tyrosine Kinases, Ser/Thr Kinases, WNT Signaling