Home   >   Kinase Inhibitors

K252A

Kinase inhibitor (pan)
Catalog No. K10-900D


Shop Online



Catalog No. Pack Size Price (USD)
K10-900D-1000 1 mg $512
K10-900D-BULK BULK Contact Us  


Overview:

Potent pan-specific protein kinase inhibitor: PKA (Ki = 18 nM), PKC (Ki = 25 nM) PKG (Ki = 20 nM) (1). Inhibits CaMK (Ki = 1.8 nM) (2) and phosphorylase kinase (IC50 = 1.7 nM) (3) as well as other kinases (4). Induces apoptosis (5). Cell permeable.

References:


1. H Kase et al. Biochem. Biophys. Res. Commun. 1987 142:436

2. Y Hashimoto et al. Biochem. Biophys. Res. Commun. 1991 181:423

3. MM Berg et al. J. Biol. Chem. 1992 267:13

4. UT Ruegg et al. Trends Pharmacol. Sci. 1989 10:218

5. T Mohri et al. Cancer Invest. 1999 17:391


CAS Registry Number:

99533-80-9


Molecular Formula:

C27H21N3O5


Appearance:

White to off-white powder


Melting Point:

N/A


Molecular Weight:

467.5


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (100 mg/ml)


Aliases:

None


Storage and Stability:

Storage, Stability and Shipping


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway, JNK/SAPK Pathway, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, PKA/PKC Pathway, Receptor Tyrosine Kinases, Ser/Thr Kinases, WNT Signaling



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox