Potent and selective inhibitor of protein kinase C (IC50 = 3.4 μM) (1). Displays antiviral activity (2). Induces apoptosis (3). Effects are light-dependent (4).
1. I Takahashi et al. Biochem. Biophys. Res. Commun. 1989 165:1207
2. G Lavie et al. Med. Res. Rev. 1995 15:111
3. P Agostinis et al. Adv. Enzyme Regul. 2000 40:157
4. P. Miskovsky Curr. Drug Targets 2002 3:55
CAS Registry Number:
Dark brown to reddish-black powder
>98% (TLC); NMR (Conforms)
May be dissolved in DMSO (25 mg/ml); or ethanol (5 mg/ml, warm)
1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro [1,10,9,8-opqra] perylene-7,14-dione
Storage and Stability:
Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 1 week.
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Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases