c-Raf1 inhibitor
Catalog No. R01-901B
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R01-901B-05 | 5 mg | $105 | |
R01-901B-25 | 25 mg | $420 | |
R01-901B-BULK | BULK | Contact Us |
Overview:
Specific inhibitor of cRaf-1 kinase (IC50=9 nM). Acts at ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective activity. Cell permeable.
References:
1. K Lackey et al. Bioorg. Med. Chem. Lett. 2000 10:223
2. PC Chen et al. J. Neurochem. 2004 90:595
CAS Registry Number:
220904-83-6
Molecular Formula:
C15H8Br2INO2
Appearance:
Off white powder
Melting Point:
267-268oC
Molecular Weight:
520.9
Purity:
98% (TLC); NMR (Conforms)
Solubilization:
May be dissolved in DMSO (50 mg/ml)
Aliases:
3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.
Molecular Structure:
There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, JAK/STAT Pathway, Ser/Thr Kinases
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