Rabbit Polyclonal Antibody
Catalog No. A34-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
A34-63R-100 | 100 ug | $215 | |
A34-63R-BULK | BULK | Contact Us |
Overview:
AXL is a member of the receptor tyrosine kinase family which has oncogenic potential and is implicated in human myeloid leukemia (1). AXL is a member of a complex signaling network that is involved in the control of cell proliferation and differentiation. Overexpression of AXL cDNA in NIH 3T3 cells induces neoplastic transformation of these cells with the concomitant appearance of a 140kDa AXL tyrosine-phosphorylated protein (2). Expression of AXL cDNA in the baculovirus system results in the expression of the appropriate recombinant protein that is recognized by anti-phosphotyrosine antibodies, confirming that the AXL protein is tyrosine phosphorylated.
Specificity:
Recognizes the AXL protein
Cross Reactivity:
Human
Host / Isotype / Clone#:
Rabbit, IgG
Immunogen:
Peptide at the N-terminal residues of human AXL protein.
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
References :
1. O'Bryan, J.P. et al: Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct;11(10):5016-31.
2. Janssen, J.W. et al:, A novel putative tyrosine kinase receptor with oncogenic potential. Oncogene. 1991 Nov;6(11):2113-20.
Zhang Zaihui et al., Discovery of novel TAM family kinase inhibitors Cancer Research April 2014 10.1158/1538-7445.AM2014-2716
Zhang Zaihui et al., Novel and selective Axl inhibitors Cancer Research April 2014 10.1158/1538-7445.AM2014-1746
Abu-Thuraiaa Afnan et al., Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion Molecular and Cellular Biology October 2014 10.1128/MCB.00764-14
Krejci Pavel et al., NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells Journal of Biological Chemistry July 2010 10.1074/jbc.M109.083626
Kosten Jonas et al., Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event ACS Chemical Neuroscience October 2014 10.1021/cn5002254
et al., Regulation of ferredoxin-catalyzed photosynthetic phosphorylations. Proceedings of the National Academy of Sciences of the United States of America December 1975
Angiogenesis, Cancer, Receptor Tyrosine Kinases
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