Rabbit Polyclonal Antibody
Catalog No. C30-362R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C30-362R-100 | 100 ul | $675 | |
C30-362R-BULK | BULK | Contact Us |
Overview:
The gene for CDK2NA generates several transcripts/proteins which differ from each other in their first exons. Three of these transcripts are generated by alternative splicing (isoform 1 a.k.a p16INK4A, isoform 2 and isoform 3 a.k.a p12), two of which are known to function as inhibitors of CDK4 kinase. One other transcript that is generated from this gene contains an alternate reading frame (ARF), with the first exon located 20kb upstream of the remainder of the gene (isoform 4 a.k.a. p14ARF, p19ARF, ARF). In spite of the structural and some functional differences, all the proteins encoded by the CDKN2A gene are involved in cell cycle G1 control.
Specificity:
Recognizes the p16 protein from human tissue
Cross Reactivity:
Human
Host Isotype / Clone#:
Rabbit, Antiserum
Immunogen:
The antibody was produced against human p16 protein (missing first 7 amino acids)
Purification:
Delipidation and defibrination
Stability:
1yr at –20oC from date of shipment
Sample Data:
Immunohistochemical analysis of formalin fixed, paraffin-embedded human prostate tissue using Anti-p16INK4A (CDKN2A) antibody (1:500 dilution).
References :
1. Serrano et al.: Nature. 1993: 366; 704-707.
Cancer, Cell Cycle
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