Rabbit Polyclonal Antibody
Catalog No. E34-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E34-63R-100 | 100 ug | $270 | |
E34-63R-BULK | BULK | Contact Us |
Overview:
EIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. EIF4E and is the rate-limiting component in protein synthesis. Overexpression of EIF4E causes malignant transformation (1). Overexpression of EIF4E in transgenic mice causes a marked increase in tumorigenesis. EIF4E is a potential physiological substrate for MNK1 and MNK2. MNK1 interacts with the EIF4F complex via its interaction with the C-terminal region of EIF4G, not through a direct interaction with EIF4E (2).
References:
1. Ruggero D, et al: The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nature Med. 10: 484-486, 2004.
2. Waskiewicz A J, et al: Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16: 1909-1920, 1997.
Specificity:
Recognizes the eIF4E protein
Cross Reactivity:
Western blot eIF4E from human and mouse cells
eIF4E from other species may also be detectable.
Host:
Rabbit
Immunogen:
Synthesized peptide corresponds to amino acid 209 of human eIF4E protein.
Purification:
Affinity Chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Representative western blot with Anti-eIF4E (1:1000) using 20 μg of Hela, 293, THP1 and 3T6 cell lysates.
There are no related publications available for this product.
Angiogenesis, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Inflammation, Neurobiology
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