Rabbit Polyclonal Antibody
Catalog No. P38-63R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P38-63R-100 | 100 ug | $270 | |
P38-63R-BULK | BULK | Contact Us |
Overview:
PTPN11 (SHP2) is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain (1). This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration (2). Mutations in this gene are a cause of Noonan syndrome, Cardiofacio-cutaneous Syndrome as well as acute myeloid leukemia.
References:
1. Dechert, U. et al: Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3. Hum. Genet. 96: 609-615, 1995.
2. Ahmad, S. et al: A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Nat. Acad. Sci. 90: 2197-2201, 1993.
Specificity:
Recognizes the SHP2 (PTPN11) protein
Cross Reactivity:
Western blot human and mouse SHP2
SHP2 from other species may also be detectable.
Host :
Rabbit
Immunogen:
Synthetic peptide corresponding to amino acids 578-582 of human SHP2
Purification:
Affinity Chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Representative Western blot with Anti-SHP2 (1:1000) using 20ng of GST-tagged human recombinant SHP1 and SHP2.
Sample Data:
Representative Western blot with Anti-SHP2 (1:1000) using 3 μg, 10 μg and 30 μg of Jurkat cell lysate.
There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601