Anti-AOS1
Rabbit Polyclonal Antibody
Catalog No. A80-63R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A80-63R-100 | 100 ug | $455 | |
| A80-63R-BULK | BULK | Contact Us |
Rabbit Polyclonal Antibody
Catalog No. A80-63R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A80-63R-100 | 100 ug | $455 | |
| A80-63R-BULK | BULK | Contact Us |
Overview:
AOS1 encodes a member of the SUMO-activating enzyme for the sumoylation of proteins that regulates protein structure and intracellular localization. AOS1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins. Sumoylation is a 2-step reaction in which the SUA1/UBA2 dimer functions as an E1 enzyme and UBC9 functions as an E2 enzyme (1). AOS1 is required for sumoylation of UBA2 by epitope-tagged sentrin-1, sentrin-2 and sentrin-3 (2).
References:
1. Okuma. et.al: In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. Biochem. Biophys. Res. Commun. 254: 693-698, 1999.
2. Gong, L. et.al: Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. FEBS Lett. 448: 185-189, 1999.
Specificity:
Recognizes the AOS1 protein
Cross Reactivity:
Western blot AOS1 from human and mouse cells
AOS1 from other species may also be detectable.
Host :
Rabbit
Immunogen:
Synthetic peptide of c-terminal amino acid sequence of human AOS1 (Q9UBE0)
Purification:
Affinity chromatography
Stability:
Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Representative western blot with Anti-AOS1 (1:5000) using 3 μg, 10 μg and 30 μg of HeLa cell lysate.
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There are no related publications available for this product.
Cancer, Neurobiology
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