Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
T01-363R-100	100 ug	$595
T01-363R-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

T01-363R-100

100 ug

$595

T01-363R-BULK

BULK

Overview:

TAK1 is a serine/threonine protein kinase that mediates signaling by TGFbeta and morphogenetic protein (BMP) (1). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (NfkB). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8 (2). Thymocytes lacking TAK1 fail to activate NfkB and JNK and are prone to apoptosis upon stimulation.

References:

1. Yamaguchi, K. et al: Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270: 2008-2011, 1995.

2. Liu, H.-H. et al: Essential role of TAK1 in thymocyte development and activation. Proc. Nat. Acad. Sci. 103: 11677-11682, 2006.

Specificity:

Recognizes the TAB1 protein

Cross Reactivity:

Human and Mouse

Host / Isotype / Clone#:

Rabbit, IgG

Immunogen:

TAB1 antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1

Purification:

Affinity chromatography

Stability:

Store at 4^oC (add 0.1% NaN₃) for several months, and at -20^oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Western blot analysis of TAB1 in 3T3 cell lysate with TAB1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.